Joint FAO/WHO Expert Committee on Food Additives (JECFA)
International (FAO/WHO) · Advisory — health-based guidance to Codex · Established 1956 · Authored by Karen Pendergrass, Institute for Contaminant Standards · www.who.int — JECFA
Quick read
JECFA is the joint expert committee of the FAO and WHO that performs international risk assessments of additives and contaminants in food. Like EFSA it sets health-based guidance — provisional tolerable weekly or monthly intakes (PTWI/PTMI) — not binding limits; its conclusions feed the Codex Alimentarius standard-setting process. Its most consequential heavy-metal action was withdrawing the lead PTWI in 2010, concluding that no level of lead intake can be considered without risk.
Mandate & scope
Convened since 1956, JECFA gives the FAO and WHO independent scientific evaluations of additives and contaminants in food. It derives provisional tolerable intakes — the word “provisional” marking incomplete data — that serve as the toxicological basis for Codex Alimentarius maximum levels. For the metals the Index tracks it maintains a cadmium PTMI of 25 µg/kg b.w./month and a methylmercury PTWI of 1.6 µg/kg b.w./week. In 2010 it withdrew the long-standing lead PTWI of 25 µg/kg b.w./week after concluding the value was no longer health-protective and that dose-response modelling showed effects on IQ and blood pressure with no identifiable threshold. JECFA’s values are advisory: they carry international weight through Codex adoption but are not themselves enforceable in any jurisdiction.
Positions across metals
| Metal | Type | Value | Instrument | Effective | Status |
|---|---|---|---|---|---|
| Lead | PTWI | withdrawn | Lead Provisional Tolerable Weekly Intake | 2010 | withdrawn |
| Cadmium | PTMI | 25 µg/kg bw/month | Provisional Tolerable Monthly Intake for Cadmium | 2010 | in-force |
| Inorganic arsenic | BMDL | see instrument | JECFA inorganic arsenic BMDL₀.₅ | — | stub |
| Methylmercury | PTWI | 1.6 µg/kg bw/week | Methylmercury Provisional Tolerable Weekly Intake | 2003 | in-force |
Where it diverges
JECFA’s intake values share EFSA’s basis (per kilogram body weight) and are the closest cross-body comparison available — for methylmercury, JECFA’s PTWI of 1.6 µg/kg b.w./week sits slightly above EFSA’s 1.3, a difference in critical study and uncertainty factors, not a substantive disagreement. They are not comparable with concentration limits (EU maximum levels, FDA action levels) expressed per kilogram of a specific food. JECFA’s 2010 lead withdrawal aligns it with EFSA’s no-threshold position; both reject the implicit reassurance of any numeric “tolerable” lead intake.
Lead
Cadmium
| Body | Type | Value | Instrument |
|---|---|---|---|
| JECFA | PTMI | 25 µg/kg bw/month | Provisional Tolerable Monthly Intake for Cadmium |
| Codex | Maximum level | see instrument | Maximum Levels for Cadmium in Food |
| EFSA | TWI | 2.5 µg/kg bw/week | Tolerable Weekly Intake for Cadmium |
| EC | Maximum level | see instrument | Commission Regulation |
| EC | Maximum level | multiple — see instrument | Cadmium maximum levels for cereals |
| EC | Maximum level | see instrument | Commission Regulation |
| EC | Maximum level | multiple — see instrument | Commission Regulation |
| EC | Maximum level | see instrument | EU Regulation 2023 915 maximum levels for contamin… |
| US EPA | Oral RfD | 1 µg/kg bw/day food | EPA IRIS — Cadmium Oral Reference Doses |
| ATSDR | MRL | 0.1 µg/kg bw/day | Minimal Risk Levels for Cadmium |
| OEHHA | Prop 65 | 4.1 µg/day oral | Cadmium Listing and Maximum Allowable Daily Level |
Inorganic arsenic
| Body | Type | Value | Instrument |
|---|---|---|---|
| JECFA | BMDL | see instrument | JECFA inorganic arsenic BMDL₀.₅ |
| EFSA | BMDL (no threshold) | no numeric threshold (BMDL basis) | Arsenic in Food |
| EC | Maximum level | see instrument | Commission Regulation |
| EC | — | multiple — see instrument | eu-2015-1006-iAs-rice |
| EC | Maximum level | see instrument | EU Regulation 2023 915 maximum levels for contamin… |
| FDA | Action level | 100 ppb | FDA Closer to Zero — 100 ppb Inorganic Arsenic Act… |
| US EPA | MCL (water) | 10 ppb | Maximum Contaminant Level for Arsenic in Drinking… |
| US EPA | — | value pending | EPA IRIS — Inorganic Arsenic Toxicological Review |
| OEHHA | Prop 65 | value pending | Inorganic Arsenic Compounds Listing |
Methylmercury
| Body | Type | Value | Instrument |
|---|---|---|---|
| JECFA | PTWI | 1.6 µg/kg bw/week | Methylmercury Provisional Tolerable Weekly Intake |
| EFSA | TWI | 1.3 µg/kg bw/week | Methylmercury Tolerable Weekly Intake |
| EC | Maximum level | see instrument | Commission Regulation |
| FDA | Action level | 1 ppm methyl mercury expressed as mercury | FDA CPG Sec. 540.600 Fish |
| US EPA | Oral RfD | 0.1 µg/kg bw/day | EPA IRIS — Methylmercury Oral Reference Dose |
Update log
| Date | Event | Instrument | Status |
|---|---|---|---|
| 2003-06-01 | Issued / in force | Methylmercury Provisional Tolerable Weekly Intake | in-force |
| 2010-06-01 | Issued / in force | Provisional Tolerable Monthly Intake for Cadmium | in-force |
| 2010-06-01 | Withdrawn | Lead Provisional Tolerable Weekly Intake | withdrawn |
Key documents
References
Positions, the update log, and key documents above are generated from the per-instrument regulation pages this body issues, via tools/build-regulator-pages.mjs. The wiki reports what JECFA has published; it does not endorse it. See HMTc separation policy for why reporting regulatory values is kept architecturally separate from certification threshold-setting.