International (FAO/WHO) · Advisory — health-based guidance to Codex · Established 1956 · Authored by Karen Pendergrass, Institute of Contaminant Standards · www.who.int
Quick read
JECFA is the joint expert committee of the FAO and WHO that performs international risk assessments of additives and contaminants in food. Like EFSA it sets health-based guidance — provisional tolerable weekly or monthly intakes (PTWI/PTMI) — not binding limits; its conclusions feed the Codex Alimentarius standard-setting process. Its most consequential heavy-metal action was withdrawing the lead PTWI in 2010, concluding that no level of lead intake can be considered without risk.
Mandate & scope
Convened since 1956, JECFA gives the FAO and WHO independent scientific evaluations of additives and contaminants in food. It derives provisional tolerable intakes — the word “provisional” marking incomplete data — that serve as the toxicological basis for Codex Alimentarius maximum levels. For the metals the Index tracks it maintains a cadmium PTMI of 25 µg/kg b.w./month and a methylmercury PTWI of 1.6 µg/kg b.w./week. In 2010 it withdrew the long-standing lead PTWI of 25 µg/kg b.w./week after concluding the value was no longer health-protective and that dose-response modelling showed effects on IQ and blood pressure with no identifiable threshold. JECFA’s values are advisory: they carry international weight through Codex adoption but are not themselves enforceable in any jurisdiction.
Positions across metals
| Metal | Type | Value | Instrument | Effective | Status |
|---|---|---|---|---|---|
| Lead | PTWI | withdrawn | Lead Provisional Tolerable Weekly Intake | 2010 | withdrawn |
| Cadmium | PTMI | 25 µg/kg bw/month | Provisional Tolerable Monthly Intake for Cadmium | 2010 | in-force |
| Inorganic arsenic | BMDL | see instrument | JECFA inorganic arsenic BMDL₀.₅ | — | stub |
| Methylmercury | PTWI | 1.6 µg/kg bw/week | Methylmercury Provisional Tolerable Weekly Intake | 2003 | in-force |
Where it diverges
JECFA’s intake values share EFSA’s basis (per kilogram body weight) and are the closest cross-body comparison available — for methylmercury, JECFA’s PTWI of 1.6 µg/kg b.w./week sits slightly above EFSA’s 1.3, a difference in critical study and uncertainty factors, not a substantive disagreement. They are not comparable with concentration limits (EU maximum levels, FDA action levels) expressed per kilogram of a specific food. JECFA’s 2010 lead withdrawal aligns it with EFSA’s no-threshold position; both reject the implicit reassurance of any numeric “tolerable” lead intake.
Lead
Cadmium
Inorganic arsenic
| Body | Type | Value | Instrument |
|---|---|---|---|
| JECFA | BMDL | see instrument | JECFA inorganic arsenic BMDL₀.₅ |
| EFSA | BMDL (no threshold) | no numeric threshold (BMDL basis) | Arsenic in Food |
| EC | Maximum level | see instrument | Commission Regulation |
| EC | — | multiple — see instrument | eu-2015-1006-iAs-rice |
| EC | Maximum level | multiple — see instrument | eu-2025-1891-inorganic-arsenic-fish-seafood |
| EC | — | multiple — see instrument | eu-fertilising-products-heavy-metal-limits-2019 |
| EC | Maximum level | see instrument | EU Regulation 2023 915 maximum levels for contamin… |
| FDA | Action level | 100 ppb | FDA Closer to Zero — 100 ppb Inorganic Arsenic Act… |
| FDA | Action level | 10 ppb | 10 ppb Inorganic Arsenic Action Level for Apple Ju… |
| US EPA | MCL (water) | 10 ppb | Maximum Contaminant Level for Arsenic in Drinking… |
| US EPA | — | value pending | EPA IRIS — Inorganic Arsenic Toxicological Review |
| OEHHA | Prop 65 | value pending | Inorganic Arsenic Compounds Listing |
Methylmercury
| Body | Type | Value | Instrument |
|---|---|---|---|
| JECFA | PTWI | 1.6 µg/kg bw/week | Methylmercury Provisional Tolerable Weekly Intake |
| EFSA | TWI | 1.3 µg/kg bw/week | Methylmercury Tolerable Weekly Intake |
| EC | Maximum level | see instrument | Commission Regulation |
| FDA | Action level | 1 ppm methyl mercury expressed as mercury | FDA CPG Sec. 540.600 Fish |
| US EPA | Oral RfD | 0.1 µg/kg bw/day | EPA IRIS — Methylmercury Oral Reference Dose |
Update log
| Date | Event | Instrument | Status |
|---|---|---|---|
| 2003-06-01 | Issued / in force | Methylmercury Provisional Tolerable Weekly Intake | in-force |
| 2010-06-01 | Issued / in force | Provisional Tolerable Monthly Intake for Cadmium | in-force |
| 2010-06-01 | Withdrawn | Lead Provisional Tolerable Weekly Intake | withdrawn |
Key documents
References
Positions, the update log, and key documents above are generated from the per-instrument regulation pages this body issues, via tools/build-regulator-pages.mjs. The wiki reports what JECFA has published; it does not endorse it. See the wiki/HMTc separation policy for why reporting regulatory values is kept architecturally separate from certification threshold-setting.
Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.
| Commit | Date | Change | Description |
|---|---|---|---|
| e317189 | 2026-08-11 | correction | 12 sections added; narrative text revised |