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Joint FAO/WHO Expert Committee on Food Additives (JECFA)

International (FAO/WHO) · Advisory — health-based guidance to Codex · Established 1956 · Authored by Karen Pendergrass, Institute for Contaminant Standards · www.who.int — JECFA Quick read JECFA is the joint expert committee of the FAO and WHO...

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Last updated: 2026-06-23
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Joint FAO/WHO Expert Committee on Food Additives (JECFA)

International (FAO/WHO) · Advisory — health-based guidance to Codex · Established 1956 · Authored by Karen Pendergrass, Institute for Contaminant Standards · www.who.int — JECFA

Quick read

JECFA is the joint expert committee of the FAO and WHO that performs international risk assessments of additives and contaminants in food. Like EFSA it sets health-based guidance — provisional tolerable weekly or monthly intakes (PTWI/PTMI) — not binding limits; its conclusions feed the Codex Alimentarius standard-setting process. Its most consequential heavy-metal action was withdrawing the lead PTWI in 2010, concluding that no level of lead intake can be considered without risk.

Mandate & scope

Convened since 1956, JECFA gives the FAO and WHO independent scientific evaluations of additives and contaminants in food. It derives provisional tolerable intakes — the word “provisional” marking incomplete data — that serve as the toxicological basis for Codex Alimentarius maximum levels. For the metals the Index tracks it maintains a cadmium PTMI of 25 µg/kg b.w./month and a methylmercury PTWI of 1.6 µg/kg b.w./week. In 2010 it withdrew the long-standing lead PTWI of 25 µg/kg b.w./week after concluding the value was no longer health-protective and that dose-response modelling showed effects on IQ and blood pressure with no identifiable threshold. JECFA’s values are advisory: they carry international weight through Codex adoption but are not themselves enforceable in any jurisdiction.

Positions across metals

MetalTypeValueInstrumentEffectiveStatus
LeadPTWIwithdrawnLead Provisional Tolerable Weekly Intake2010withdrawn
CadmiumPTMI25 µg/kg bw/monthProvisional Tolerable Monthly Intake for Cadmium2010in-force
Inorganic arsenicBMDLsee instrumentJECFA inorganic arsenic BMDL₀.₅stub
MethylmercuryPTWI1.6 µg/kg bw/weekMethylmercury Provisional Tolerable Weekly Intake2003in-force

Where it diverges

JECFA’s intake values share EFSA’s basis (per kilogram body weight) and are the closest cross-body comparison available — for methylmercury, JECFA’s PTWI of 1.6 µg/kg b.w./week sits slightly above EFSA’s 1.3, a difference in critical study and uncertainty factors, not a substantive disagreement. They are not comparable with concentration limits (EU maximum levels, FDA action levels) expressed per kilogram of a specific food. JECFA’s 2010 lead withdrawal aligns it with EFSA’s no-threshold position; both reject the implicit reassurance of any numeric “tolerable” lead intake.

Lead

BodyTypeValueInstrument
JECFAPTWIwithdrawnLead Provisional Tolerable Weekly Intake
EFSABMDL (no threshold)no numeric threshold (BMDL basis)Lead in Food
ECMaximum levelsee instrumentCommission Regulation
ECMaximum level0.2 mg/kg wet weightLead maximum level for cereals and pulses
ECMaximum levelmultiple — see instrumentLead Maximum Levels for Infant and Young-Child Foods
ECMaximum levelmultiple — see instrumentCommission Regulation
ECMaximum levelsee instrumentEU Regulation 2023 915 maximum levels for contamin…
FDAAction level10 ppbFDA Closer to Zero — 10 ppb Lead Action Level for…
FDAAction level20 ppbFDA Closer to Zero — 20 ppb Lead Action Level for…
FDAAction level20 ppbFDA Closer to Zero — 20 ppb Lead Action Level for…
FDA50 ppbFDA Juice HACCP — 50 ppb Lead Guidance Context for…
FDAAction levelmultiple — see instrumentFDA 2022 Draft — Lead Action Levels for Juice
FDAAction levelsee instrumentFDA 2025 Lead Action Levels for Processed Food Int…
US EPAOral RfDvalue pendingEPA IRIS — Lead
OEHHAProp 65multiple — see instrumentLead and Lead Compounds Listing

Cadmium

BodyTypeValueInstrument
JECFAPTMI25 µg/kg bw/monthProvisional Tolerable Monthly Intake for Cadmium
CodexMaximum levelsee instrumentMaximum Levels for Cadmium in Food
EFSATWI2.5 µg/kg bw/weekTolerable Weekly Intake for Cadmium
ECMaximum levelsee instrumentCommission Regulation
ECMaximum levelmultiple — see instrumentCadmium maximum levels for cereals
ECMaximum levelsee instrumentCommission Regulation
ECMaximum levelmultiple — see instrumentCommission Regulation
ECMaximum levelsee instrumentEU Regulation 2023 915 maximum levels for contamin…
US EPAOral RfD1 µg/kg bw/day foodEPA IRIS — Cadmium Oral Reference Doses
ATSDRMRL0.1 µg/kg bw/dayMinimal Risk Levels for Cadmium
OEHHAProp 654.1 µg/day oralCadmium Listing and Maximum Allowable Daily Level

Inorganic arsenic

BodyTypeValueInstrument
JECFABMDLsee instrumentJECFA inorganic arsenic BMDL₀.₅
EFSABMDL (no threshold)no numeric threshold (BMDL basis)Arsenic in Food
ECMaximum levelsee instrumentCommission Regulation
ECmultiple — see instrumenteu-2015-1006-iAs-rice
ECMaximum levelsee instrumentEU Regulation 2023 915 maximum levels for contamin…
FDAAction level100 ppbFDA Closer to Zero — 100 ppb Inorganic Arsenic Act…
US EPAMCL (water)10 ppbMaximum Contaminant Level for Arsenic in Drinking…
US EPAvalue pendingEPA IRIS — Inorganic Arsenic Toxicological Review
OEHHAProp 65value pendingInorganic Arsenic Compounds Listing

Methylmercury

BodyTypeValueInstrument
JECFAPTWI1.6 µg/kg bw/weekMethylmercury Provisional Tolerable Weekly Intake
EFSATWI1.3 µg/kg bw/weekMethylmercury Tolerable Weekly Intake
ECMaximum levelsee instrumentCommission Regulation
FDAAction level1 ppm methyl mercury expressed as mercuryFDA CPG Sec. 540.600 Fish
US EPAOral RfD0.1 µg/kg bw/dayEPA IRIS — Methylmercury Oral Reference Dose

Update log

DateEventInstrumentStatus
2003-06-01Issued / in forceMethylmercury Provisional Tolerable Weekly Intakein-force
2010-06-01Issued / in forceProvisional Tolerable Monthly Intake for Cadmiumin-force
2010-06-01WithdrawnLead Provisional Tolerable Weekly Intakewithdrawn

Key documents

References

Positions, the update log, and key documents above are generated from the per-instrument regulation pages this body issues, via tools/build-regulator-pages.mjs. The wiki reports what JECFA has published; it does not endorse it. See HMTc separation policy for why reporting regulatory values is kept architecturally separate from certification threshold-setting.