JECFA inorganic arsenic BMDL₀.₅ (lower-limit benchmark dose)

Overview

Stub. Pending dedicated ingest of the JECFA BMDL₀.₅ derivation for inorganic arsenic, which is the operative reference value JECFA retained after withdrawing the PTWI of 15 µg/kg b.w./week in 2010 (72nd meeting) (JECFA 82nd). The BMDL framework expresses the lower 95% confidence limit on the dose corresponding to a 0.5 percent increased incidence of lung cancer in epidemiological data.

The page should populate with:

• Numerical BMDL₀.₅ value (range typically reported as 2 to 7 µg/kg b.w./day depending on the underlying epidemiological dataset).
• The 2010 withdrawal of the iAs PTWI and the rationale: dietary exposures in many populations are at or above the BMDL, leaving no margin to support a “tolerable” framing.
• Use by national regulators (FDA Closer to Zero, EFSA contaminant assessments) as the de-facto health-based reference value for iAs.

See Arsenic for the cross-source iAs synthesis and JECFA 82nd for the 82nd-meeting context that referenced this BMDL framework.

References

Works cited in this page’s text, in first-appearance order. This is not the full corpus for this page; it is only what the prose above draws on. The complete set of sources is listed under Sources below. Each title links to its source record, which carries the ingest receipt, the extracted values, and the file hash of the document it was built from.

1. Safety Evaluation of Certain Food Additives (Arsenic), 82nd Meeting of JECFAJoint FAO/WHO Expert Committee on Food Additives · WHO Food Additives Series 73 · 2017 · www.who.intGovernment

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.