Overview
Stub. Pending dedicated ingest of the JECFA BMDL₀.₅ derivation for inorganic arsenic, which is the operative reference value JECFA retained after withdrawing the PTWI of 15 µg/kg b.w./week in 2010 (72nd meeting) (JECFA 82nd). The BMDL framework expresses the lower 95% confidence limit on the dose corresponding to a 0.5 percent increased incidence of lung cancer in epidemiological data.
The page should populate with:
- Numerical BMDL₀.₅ value (range typically reported as 2 to 7 µg/kg b.w./day depending on the underlying epidemiological dataset).
- The 2010 withdrawal of the iAs PTWI and the rationale: dietary exposures in many populations are at or above the BMDL, leaving no margin to support a “tolerable” framing.
- Use by national regulators (FDA Closer to Zero, EFSA contaminant assessments) as the de-facto health-based reference value for iAs.
See Arsenic for the cross-source iAs synthesis and JECFA 82nd for the 82nd-meeting context that referenced this BMDL framework.
References
Works cited in this page’s text, in first-appearance order. Each title links to its source record, which carries the ingest receipt, the extracted values, and the file hash of the document it was built from.
Update history
No substantive edit history is available in this build. The full commit record is available in git.