EFSA — Arsenic in Food (2009), No-PTWI Position

Overview

The EFSA CONTAM Panel concluded in October 2009 that the prior JECFA provisional tolerable weekly intake of 15 µg inorganic arsenic per kilogram body weight per week is no longer appropriate, on the basis that inorganic arsenic causes cancer (lung, bladder, skin) at exposures below the PTWI (EFSA 2009 arsenic opinion). EFSA reports BMDL01 values for cancer endpoints rather than setting a TWI: BMDL01 for inorganic arsenic-related lung, skin, and bladder cancers ranges 0.3 to 8 µg inorganic arsenic (iAs)/kg b.w./day depending on endpoint and study selection (EFSA 2009 arsenic opinion).

European inorganic arsenic exposure ranges 0.13 to 0.56 µg/kg b.w./day for average adult consumers across 19 Member States, 0.37 to 1.22 for 95th-percentile consumers; children under three years are exposed at 2 to 3 times adult per-kg rates due to greater per-kg food intake (EFSA 2009 arsenic opinion). Rice and rice-based infant cereal is the dominant single dietary source of inorganic arsenic for US infants (FDA iAs 2020).

Sources

• EFSA As 2009 — EFSA CONTAM Panel, 2009. Scientific Opinion on Arsenic in Food.

References

Works cited in this page’s text, in first-appearance order. See Sources for this page’s source inventory. Each title links to a source record with bibliographic details, reported findings, and document provenance.

1. Scientific Opinion on Arsenic in FoodEFSA Panel on Contaminants in the Food Chain (CONTAM) · EFSA Journal 2009;7(10):1351 · 2009 · doi.org/10.2903/j.efsa.2009.1351Government
2. Inorganic Arsenic in Rice Cereals for Infants: Action Level, Guidance for IndustryU.S. Food and Drug Administration · 2020 · www.fda.govGuidance

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