EPA IRIS — Inorganic Arsenic Toxicological Review (January 2025)

Overview

The January 2025 EPA IRIS Toxicological Review of Inorganic Arsenic (EPA/635/R-25/005Fa, CASRN 7440-38-2) is the finalized US Environmental Protection Agency reassessment of inorganic arsenic toxicity (EPA IRIS iAs 2025). It supersedes prior IRIS arsenic values that had been operative for decades, and represents the US federal scientific anchor for inorganic arsenic dose-response that downstream EPA, FDA, and state regulatory actions reference (EPA IRIS iAs 2025).

The full quantitative outputs (oral RfD, inhalation RfC, oral cancer slope factor, inhalation unit risk, critical study identification per endpoint) require detailed extraction from the approximately 100+ page review document and are pending consolidation (EPA IRIS iAs 2025). Once those values are extracted from the full text, this regulation page will record them with the verbatim agency-stated values.

Sources

• EPA IRIS iAs 2025 — EPA, January 2025. IRIS Toxicological Review of Inorganic Arsenic (EPA/635/R-25/005Fa).

References

Works cited in this page’s text, in first-appearance order. This is not the full corpus for this page; it is only what the prose above draws on. The complete set of sources is listed under Sources below. Each title links to its source record, which carries the ingest receipt, the extracted values, and the file hash of the document it was built from.

1. IRIS Toxicological Review of Inorganic ArsenicU.S. Environmental Protection Agency, Center for Public Health and Environmental Assessment · EPA/635/R-25/005Fa, U.S. Environmental Protection Agency, Integrated Risk Information System · 2025 · iris.epa.govGovernment

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.