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Heavy Metal Index

Tomato

Ingredient

This ingredient stub was created during the FDA FY2018-FY2020 Total Diet Study element-results ingest so future source ingests have a stable destination for this food matrix.

Page snapshot
Corpus sources39

Overview

This ingredient stub was created during the FDA FY2018-FY2020 Total Diet Study element-results ingest so future source ingests have a stable destination for this food matrix. FDA reports this item as TDS Food 117, “Tomato, raw.” FY2018-FY2020 TDS Elements Analytical Results

Why this commodity accumulates heavy metals

Tomato is a botanical fruit grown close to the soil surface, and its metal burden is determined primarily by the chemical composition of the growing medium. Lead and cadmium enter tomato tissue through root uptake from contaminated soils; both metals are taken up passively along with nutrients, with Cd uptake facilitated by the same membrane transporters that move zinc and calcium into root cells. Tomatoes are generally considered a low-to-moderate accumulator for both Pb and Cd relative to leafy vegetables or root crops, because the fruit forms a physical separation from the root system and metals must be transported through multiple plant compartments to reach the edible portion. However, tomatoes are a dietary staple consumed in large volumes by diverse populations, meaning that even low per-gram concentrations contribute meaningfully to aggregate dietary exposure across the population. Soil organic matter, pH, and proximity to industrial or road-traffic Pb sources are the primary drivers of field-level variance.

Heavy metal contamination profile

Per-analyte snapshot derived from the machine-readable contamination_profile in the frontmatter above. data gap indicates the literature has been reviewed for this commodity-analyte combination and no usable occurrence data was found (a finding, not a placeholder). The Key sources column shows the top 2-3 contributing sources by year and sample size, with numbered wikilink aliases.

AnalyteCoverageTypical (ppb)ConfidenceKey sources
Pbn=40–5medium1, 2, 3, 4
Cdn=90.6–6.7medium1, 2, 3
iAsdata gap
tAsn=30–3low1, 2, 3
tHgn=30–1low1, 2, 3
Nin=30–30low1, 2, 3
Aldata gap
Crn=30–30low1, 2, 3
Snn=350–400medium1, 2, 3
Un=20low

Synthesis basis and censoring treatment

The FDA Total Diet Study reported every flagged analyte below its reporting limit in all 27 raw-tomato composites: lead below 4 ppb, total arsenic below 3 ppb, total mercury below 1 ppb, nickel below 40 ppb, and total chromium below 50 ppb (FDA 2022). These non-detects were coded as zeros and are corrected here to left-censored bounds. Tomato fruit is a low accumulator: a Spanish greenhouse trial found lead, total arsenic, nickel, and total chromium all below the limit of quantification in tomato fruit even under seaweed biofertilizer amendment (Rodriguez-Rodriguez et al. 2026), the Jiaozuo survey placed solanaceous fruits at the low end of the vegetable distribution (Wu 2024), and the New Zealand survey found Solanum lead and mercury below the detection limit (Dearing et al. 2025).

The synthesized central ranges are lead 0 to 5 ppb, total arsenic 0 to 3 ppb, total mercury 0 to 1 ppb, nickel 0 to 30 ppb, and total chromium 0 to 30 ppb, all fresh weight. Lead carries medium confidence because four datasets agree on a near-zero value; the other analytes stay low because their commercial evidence is largely censored. The Tehran supermarket survey reported markedly higher tomato lead of 79 to 241 ppb, nickel of 161 to 232 ppb, and chromium of 234 to 412 ppb fresh weight (Alimohammadi et al. 2018), and coal-plant-adjacent mercury appears in hotspot surveys; both are treated as elevated right-tail context and are excluded from the central estimates.

FDA TDS FY2018-FY2020 Evidence

The normalized row-level data for this TDS food is stored in data/evidence/fda_tds_fy2018_2020_element_results_samples.csv, with per-food/per-analyte summaries in data/evidence/fda_tds_fy2018_2020_summary_by_food_analyte.csv. Concentrations are retained as FDA reported them, with the reporting-limit column preserved separately; reported zeroes are not rewritten as <LOD unless a source explicitly says to do so. FY2018-FY2020 TDS Elements Analytical Results

Routing

This node is linked from the ingredient index and the FDA TDS source routing table.

Contamination Profile State

Per-analyte state — populated, in progress, or declared data gap — is carried authoritatively in the machine-readable contamination_profile frontmatter and the contamination-profile table above. Ingredient-level values belong here; finished-product values belong on the relevant product-category page.

FDA TDS FY2018-FY2020 Occurrence Values

FDA Total Diet Study FY2018-FY2020 reports prepared/composite-food concentration distributions for this ingredient as TDS food “Tomato, raw” (FY2018-FY2020 TDS Elements Analytical Results). Values are in ppb-equivalent on the basis FDA reported. The full sample-level data are stored in data/evidence/fda_tds_fy2018_2020_element_results_samples.csv; per-analyte distributions in data/evidence/fda_tds_fy2018_2020_summary_by_food_analyte.csv. These distributions count as one source under Persistent Wiki Ingest Rule synthesis discipline; numerical values stay in body scratch until a second independent source is integrated.

MetalnminmaxSchema
Cd2707.6in profile
Cr2700in profile
Ni2700in profile
Pb2700in profile
U2700in profile
tAs2700in profile
tHg2700in profile

Ranges by source, region, and variety

No quantified data on this lever in the current corpus; section will be expanded when relevant evidence is ingested.

Processing effects

Fresh tomato transitions into several processed forms that concentrate or dilute metals in different proportions. Dicing, crushing, and cooking in water do not significantly change metal concentrations on a wet-weight basis, but evaporation during sauce or paste production concentrates all solutes proportionally. Tomato paste, which undergoes substantial water removal, will carry higher ppb values for any metal present in the raw fruit simply because the same mass of metal is distributed across less water. Canning introduces a separate concern: the heat sterilisation step required for shelf-stable canned tomatoes in tinplate cans can drive tin (Sn) migration from the can lining into the acidic tomato matrix; this pathway is documented for canned tomato products more broadly and is discussed on the Tomato soup page. Lacquer-lined or BPA-free can coatings substantially reduce Sn migration.

Ingredient-derivative risk

The primary derivatives of tomato in food manufacturing are tomato paste (concentrated), tomato puree, crushed tomatoes, tomato sauce, ketchup, tomato juice, sun-dried tomatoes, and tomato powder. Because metals do not volatilize during cooking, any derivative that reduces water content relative to fresh tomato will show proportionally elevated concentrations on a wet-weight basis. Sun-dried tomatoes and tomato powder, which remove nearly all free water, would be expected to carry the highest per-gram concentrations of any metal present in the raw fruit. Tomato soup and tomato-based sauces occupy an intermediate position. Ketchup, which is typically made from concentrated paste diluted with vinegar and other ingredients, presents a blended metal profile. The Tomato soup page carries occurrence data specific to the canned condensed soup form.

Mitigation options

Sourcing levers

Tomatoes grown in soils with low background Pb and Cd concentrations, verified by supplier soil testing, represent the primary sourcing lever. Industrial or peri-urban cultivation sites near smelters, highways, or legacy industrial land carry higher Pb risk. Specification of growing-region origin and soil metal testing at supplier qualification is the upstream control.

Agronomic levers

Soil pH management (maintaining pH above 6.5) reduces Cd and Pb bioavailability through adsorption to soil particles. Liming contaminated soils is an established agronomic practice for reducing Cd uptake across vegetable crops. Organic matter additions similarly reduce metal bioavailability. These interventions are most relevant where supplier soils are moderately elevated rather than severely contaminated.

Processing levers

No quantified data on this lever in the current corpus; section will be expanded when relevant evidence is ingested.

Formulation levers

No quantified data on this lever in the current corpus; section will be expanded when relevant evidence is ingested.

Testing and QC levers

Because tomato is a high-volume dietary staple, lot-level testing of raw tomato paste or puree used in high-volume products is warranted for Pb and Cd. Third-party ICP-MS testing of finished paste concentrates provides the most actionable signal for downstream product manufacturers.

Packaging and storage levers

For canned tomato products, specifying lacquer-lined or polymer-coated cans eliminates the Sn migration pathway from tinplate. This is addressed in more detail on Tomato soup.

Regulatory limits that apply

The European Union sets maximum levels for Pb and Cd in fresh tomatoes under EU Regulation 2023/915 maximum levels for contaminants in food: Pb at 0.10 mg/kg (100 ppb) and Cd at 0.050 mg/kg (50 ppb) on a fresh-weight basis. These limits apply to tomato as a fresh fruit or vegetable placed on the EU market. Processed tomato products such as paste or sauce are governed by separate matrix-specific provisions in EU contaminant regulations. No FDA action level specific to raw tomato is currently in force; FDA Closer to Zero — Program Overview guidance addresses Pb in processed baby foods rather than raw commodities. Codex Alimentarius — Maximum Levels for Cadmium in Food provides the international Codex Cd maximum for vegetables.

References

Works cited in this page’s text, in first-appearance order. This is not the full corpus for this page; it is only what the prose above draws on. The complete set of sources is listed under Sources below. Each title links to its source record, which carries the ingest receipt, the extracted values, and the file hash of the document it was built from.

  1. FY2018-FY2020 TDS Elements Analytical ResultsU.S. Food and Drug Administration · FDA Total Diet Study · 2022 · www.fda.govDataset
  2. Trace Element Content in Tomato Fruit Grown with Sargassum-Based BiofertilizerRodríguez-Rodríguez R, Sánchez-García A, Ruiz-Lozano JM, and Aroca R · Agronomy · 2026 · doi.org/10.3390/plants15060901Review
  3. Contamination of Heavy Metal(Loid)S in Cereals, Vegetables, and Legumes Purchased from Local Markets of Jiaozuo, China and The Associated Health Risk AssessmentWu Z · International Journal of Natural Resources and Environmental Studies, 2(1): 180-200 · 2024 · doi.org/10.62051/10.62051/ijnres.v2n1.21Review
  4. Assessment of Heavy Metals in Organic and Non-Organic Vegetables Post Severe Tropical Cyclone Gabrielle: A cross-sectional comparative analysisDearing C, Ye Z, and Robertshaw G · F1000Research · 2025 · doi.org/10.12688/f1000research.175538.1Review
  5. Heavy metal(oid)s concentration in Tehran supermarket vegetables: carcinogenic and non-carcinogenic health risk assessmentAlimohammadi M, Younesian M, Madihi-Bidgoli S, Nabizadeh Nodehi R, Jahed Khaniki GR, Hadi M, et al. · Toxin Reviews · 2018 · doi.org/10.1080/15569543.2018.1522644Review

Sources

Auto-generated from source-page frontmatter. The "Used on this page for" column is populated by the orchestrator's POPULATE-SOURCE-LEGEND action; pending entries appear as *[awaiting synthesis]*.

#CitationYearTypeUsed on this page for
1Rodríguez-Rodríguez et al. 2026. Trace Element Content in Tomato Fruit Grown with Sargassum-Based Biofertilizer, Agronomy2026Peer-reviewedMeasured tAs, Cd, Pb, Ni, and Cr in greenhouse tomatoes grown with Sargassum biofertilizer vs controls (Spain); all five metals below LOQ in tomato fruit from both treatment groups
2Barber et al. 2025. Toxic elements in baby and young children’s foods in the US and correlation to ingredients, Food Additives & Contaminants: Part B2025Peer-reviewedUS tAs, iAs, Cd, tHg, MeHg, Pb, Tl occurrence in Non-targeted 2023 FDA convenience survey of 566 foods intended for babies, young children, pregnant women, and nursing mothers:… (n=566)
3Shavali-gilani et al. 2025. Investigation of heavy metal levels in canned tomato paste, olives, and pickled cucumbers, Scientific Reports2025Peer-reviewedIR Pb, Cd, tHg, Sn occurrence in 49 samples of canned tomato paste, canned olives, and pickled cucumbers from the 5 most popular brands, purchased… (n=49)
4Fatai et al. 2024. Concentration and Health Risk Assessment of Selected Heavy Metals (HMs) in African spinach (Amaranthus hybridus) and Tomato (Solanum lycopersicum) Grown around Ashaka Community, Gombe State, Nigeria, Journal of Chemistry and Nutritional Biochemistry2024Peer-reviewedNG Cu, Ni, Zn, Cd, Cr, Pb occurrence in African spinach and tomato composite samples collected around Ashaka community, Gombe State, Nigeria (n=2)
5Kangre 2024. Heavy metal migration, exposure, and health risk through canned tomato mix under different marketing display models, MPhil Thesis, University of Education Winneba, Ghana2024ThesisGH Pb, Sn occurrence in 32 canned Tasty Tom tomato mix samples from Effutu Municipality (Winneba), Ghana: 16 from sunlight-exposed shops, 16 from… (n=32)
6Rossini-Oliva et al. 2024. Is it healthy urban agriculture? Human exposure to potentially toxic elements in urban gardens from Andalusia, Spain, Environmental Science and Pollution Research2024Peer-reviewedES As, Cd, Pb, Ni, Cr, Cu, Co, Ba, B, Mo, Zn occurrence in Edible vegetables and topsoils from urban gardens in Seville, Cordoba, Huelva, and Riotinto mining area, Andalusia, Spain; 2021–2023 (n=282)
7Salem et al. 2024. Influence of the use of remediated soil and agricultural drainage water on the safety of tomato fruits, Environmental Science and Pollution Research2024Peer-reviewedEG Cd, Ni, Cu, Zn, Pb occurrence in Tomato fruits (Solanum lycopersicum var. cerasiforme) grown in contaminated soil with different bioremediation treatments; greenhouse and field experiments;…
8Samma et al. 2024. Evaluating Soil-Vegetable Contamination with Heavy Metals in Bogura, Bangladesh: A Risk Assessment Approach, Environmental Health Insights2024Peer-reviewedBD Pb, Cr, Cu occurrence in Composite vegetable and soil samples from 5 vegetable species across 6 upazilas in Bogura district, Bangladesh (northern industrial… (n=30)
9Wu 2024. Contamination of Heavy Metal(Loid)S in Cereals, Vegetables, and Legumes Purchased from Local Markets of Jiaozuo, China and The Associated Health Risk Assessment, International Journal of Natural Resources and Environmental Studies, 2(1): 180-2002024Peer-reviewedCN Pb, Cd, Cr, tAs, tHg, Ni, Cu, Zn occurrence in 244 retail food samples purchased from 13 sampling points (6 supermarkets, 6 farmers’ markets, 1 wholesale market) across… (n=244)
10Abdolahpour et al. 2023. The health risk assessment of heavy metals in vegetables grown in Babol city, Iran, International Archives of Health Sciences2023Peer-reviewedIR Pb, Cd, Cu, Zn occurrence in Eight vegetable types (parsley, spinach, basil, tomatoes, cucumbers, potatoes, onions, beans) from Babol, Mazandaran Province, northern Iran; 4… (n=32)
11Ahmed et al. 2023. Trace metal concentrations in tomato fruits irrigated with industrial wastewater in Cairo and health risk assessment, Environmental Science and Pollution Research2023Peer-reviewedEG Pb, Cd, Cr, Ni, Cu, Fe, Mn, Zn, Co occurrence in Tomato fruits from wastewater-irrigated farms in Cairo, Egypt
12Ammar et al. 2023. Investigation of Element Migration from Aluminum Cooking Pots Using ICP-MS, Applied Sciences (MDPI)2023Peer-reviewedSA Al, Fe, As, Cd, Pb occurrence in Eight cooked-food test conditions (AC-1 through APP-5) using four aluminum cooking pots — two traditional pots (codes AC,… (n=16)
13Doris et al. 2023. Determination of cadmium and lead in vegetables marketed in Quito, Ecuador, Revista Internacional de Contaminacion Ambiental2023Peer-reviewedEC Cd, Pb occurrence in Tomato, carrot, and lettuce samples marketed in Quito, Ecuador
14Bazie et al. 2022. Evaluation of metallic trace elements contents in some major raw foodstuffs in Burkina Faso and health risk assessment, Scientific Reports2022Peer-reviewedBF Cd, Pb, Cr, Ni occurrence in rice, maize, peanut, tomato, and dried fish samples in Burkina Faso (n=222)
15Bora et al. 2022. Quantification and Reduction in Heavy Metal Residues in Some Fruits and Vegetables: A Case Study Galați County, Romania, Horticulturae2022Peer-reviewedRO/EU tAs, Cd, Pb, Zn occurrence in 80 fruit and vegetable samples from Galați County, Romania (45 from vegetable/fruit market, 35 from amateur farmers), collected… (n=80)
16FDA 2022. FY2018-FY2020 TDS Elements Analytical Results, FDA Total Diet Study2022Government datasetPrimary occurrence data for Pb, Cd, Ni, Cr, U, tAs, and tHg in tomato (TDS food item; n varies by analyte)
17Munir et al. 2022. Heavy Metal Contamination of Natural Foods Is a Serious Health Issue: A Review, Sustainability2022ReviewPb, Cd, tAs, tHg, Cr, Ni, Cu, Zn, Fe, Mn, Co occurrence in Narrative review synthesizing previously published occurrence values and toxicology mechanisms for heavy metals in plant-based foods, with worked…
18Clair-Caliot et al. 2021. Uptake of Arsenic by Irrigated Vegetables and Cooked Food Products in Burkina Faso, Frontiers in Water2021Peer-reviewedBF tAs occurrence in Greenhouse-cultivated vegetables (7 species × 4 As irrigation concentrations × 6 replicates) at 2iE, Ouagadougou, Burkina Faso (dry… (n=168)
19Rusin et al. 2021. Concentration of cadmium and lead in vegetables and fruits, Scientific Reports2021Peer-reviewedPL Cd, Pb occurrence in 370 samples drawn from the Polish retail market and analysed under Polish State Sanitary Inspection (n=292 by the… (n=370)
20EL et al. 2020. Aluminum exposure from food in the population of Lebanon, Toxicology Reports2020Peer-reviewedLB Al occurrence in Ninety-seven food items collected May–September 2018 from the Beirut retail market (105 sampled; 8 discarded for turbidity), comprising… (n=97)
21Grochowska-Niedworok et al. 2020. Assessment of cadmium and lead content in tomatoes and tomato products, Roczniki Państwowego Zakładu Higieny (Annals of the National Institute of Hygiene)2020Peer-reviewedPL/EU Pb, Cd occurrence in Fresh and processed tomato products purchased in Polish retail and local markets; variety includes conventional, organic, multiple varieties,… (n=25)
22Heshmati et al. 2020. Concentration and Risk Assessment of Potentially Toxic Elements, Lead and Cadmium, in Vegetables and Cereals Consumed in Western Iran, Journal of Food Protection 83(1):101-1072020Peer-reviewedIR/EU Pb, Cd occurrence in Four hundred composite food samples — 50 each of eight commodities (potato Solanum tuberosum, onion Allium cepa, tomato… (n=400)
23Uroko et al. 2020. Quantification of Heavy Metals in Canned Tomato Paste Sold in Ubani-Umuahia, Nigeria, Journal of Bio-Science2020Peer-reviewedNG Pb, Ni, Cu, Co, Fe, Cr, Cd, Mn, Zn occurrence in Ten coded canned tomato-paste products purchased from Ubani-Umuahia market, Nigeria. (n=10)
24Vaishali et al. 2020. A Comparative Study on Presence of Heavy Metals Lead and Cadmium in Tomato Ketchups used by Street Vendors of Delhi NCR, Journal of Advanced Research in Medical Science & Technology2020Peer-reviewedIN Pb, Cd occurrence in Tomato ketchup from street vendors in Delhi, Noida, Gurugram, and Faridabad (3 samples per locale) (n=12)
25Dordevic et al. 2019. Aluminum contamination of food during culinary preparation: Case study with aluminum foil and consumers’ preferences, Food Science & Nutrition2019Peer-reviewedCZ/EU Al occurrence in Eleven food types (Atlantic salmon fillet, mackerel, duck breasts with and without skin, cheese Hermelín, fresh tomato, fresh… (n=11)
26Alimohammadi et al. 2018. Heavy metal(oid)s concentration in Tehran supermarket vegetables: carcinogenic and non-carcinogenic health risk assessment, Toxin Reviews2018Peer-reviewedIR tAs, Cd, Cr, Cu, Ni, Pb, Zn occurrence in Six vegetable types (lettuce, cabbage, tomato, cucumber, potato, carrot; n=16 each, 96 total) collected from Tehran central fruit… (n=96)
27Ametepey et al. 2018. Determination of heavy metals in selected vegetables from markets in Tamale Metropolis, Ghana, International Journal of Food Contamination2018Peer-reviewedMeasured Cd, Pb, Cr, and Ni in tomato from three markets in Tamale, Ghana (n=75 total samples across 5 vegetables); provides West African occurrence context
28Muniz et al. 2018. Evaluation of metals in tomato sauces stored in different types of packaging, Food Science and Technology2018Peer-reviewedBR tAs, Cd, Pb, Cr, Ni, Sb, Sn occurrence in 20 retail tomato sauce samples in 4 packaging types (plastic, metallic/canned, cellulosic, glass), 2 brands, Rio de Janeiro… (n=20)
29Li et al. 2017. Mercury pollution in vegetables, grains and soils from areas surrounding coal-fired power plants, Scientific Reports2017Peer-reviewedCN tHg occurrence in Pooled vegetable, grain, and soil samples from six open-field locations within 10 km of two coal-fired power plants…
30Salhotra et al. 2017. Determination of heavy metals contamination in some vegetables and fruits samples from the market of Jagdalpur, Chhattisgarh State, IOSR Journal of Applied Chemistry2017Peer-reviewedIN Pb, Cd, Cu, Fe, Co occurrence in vegetable and fruit samples from Jagdalpur market, Chhattisgarh State, India (n=ten vegetables and fruits)
31Jaishree et al. 2015. Heavy metal accumulation in vegetables irrigated with industrial effluent, International Journal of Innovative Research in Science, Engineering and Technology2015Peer-reviewedIN Cd, Ni, Pb, Cu, Cr, Mn, Zn occurrence in Vegetables and wheat grown under industrial-effluent irrigation conditions in India
32Mohod 2015. A review on the concentration of the heavy metals in vegetable samples like spinach and tomato grown near the area of Amba Nalla of Amravati City, International Journal of Innovative Research in Science, Engineering and Technology2015Peer-reviewedIN Pb, Cd, Cu, Zn occurrence in spinach leaf and tomato grown near Amba Nalla, Amravati City, India (n=not reported in abstract)
33Hobbie et al. 2014. Stainless Steel Leaches Nickel and Chromium into Foods During Cooking, Society of Toxicology 2014 Annual Meeting (poster)2014Conference proceedingsUS Ni, Cr occurrence in Laboratory-controlled cooking trials using three NIST stainless-steel reference materials (NIST 121d and 123c, both grade-304 equivalents; NIST 160b,…
34Bassioni et al. 2012. Risk Assessment of Using Aluminum Foil in Food Preparation, International Journal of Electrochemical Science2012Peer-reviewedAE/EG Al occurrence in Six experimental cooking-solution recipes (variants on 40% minced-beef extract + tomato juice + citric acid + NaCl, with… (n=6)
35Buculei et al. 2012. Study regarding the tin and iron migration from metallic cans into foodstuff during storage, Journal of Agroalimentary Processes and Technologies, 18(4), 299-3032012Peer-reviewedRO Sn, Fe occurrence in Four canned product types (peas, tomato paste, pork in own juice, pork liver pate) packed in three-piece tinplate… (n=4)
36Loutfy et al. 2012. Analysis and exposure assessment of some heavy metals in foodstuffs from Ismailia city, Egypt, Toxicological & Environmental Chemistry2012Peer-reviewedEG Cd, Pb, Cr, Zn, Cu occurrence in About 350 locally produced individual food samples purchased in 2007 from four local markets around Ismailia city, Egypt,… (n=117)
37David et al. 2008. The heavy metals analyses in canned tomato paste, Journal of Agroalimentary Processes and Technologies2008Peer-reviewedRO/IT Pb, Cd, Sn, Al, Cr, Fe, Zn, tAs occurrence in Five commercial canned tomato paste and tomato sauce products sampled from the Romanian retail market in 2008: three… (n=5)
38JECFA 2006. Evaluation of certain food contaminants — Sixty-fourth report of the Joint FAO/WHO Expert Committee on Food Additives, WHO Technical Report Series 930 (Sixty-fourth meeting of JECFA, Rome, 8-17 February 2005)2006Government reportinternational Cd, Sn occurrence in Cadmium: raw or aggregated occurrence data submitted to GEMS/Food by Australia, Canada, Germany, Japan, New Zealand, Norway, USA,…
39Blunden et al. 2003. Tin in canned food: a review and understanding of occurrence and effect, Food and Chemical Toxicology, Vol. 41, Issue 12, pp. 1651-16622003Peer-reviewedUK/EU/US Sn occurrence in Narrative review of tin-in-canned-food literature commissioned by ITRI Ltd (the International Tin Research Institute) compiling published primary clinical,…

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.

CommitDateChangeDescription
a8052bb2026-08-09major5 sources added; contamination-profile values revised; 22 sections added