Zhang and colleagues exposed mice to 10 mg/L cadmium in drinking water for 10 weeks. The abstract states that this exposure increased hepatic triacylglycerol, serum free fatty acids, and serum triacylglycerol, and increased messenger RNA for genes involved in fatty-acid and triacylglycerol synthesis in the liver.
On the gut microbiome, the abstract states that Firmicutes and gamma-proteobacteria decreased significantly in feces after 4 weeks, and that Firmicutes decreased significantly in cecum contents after 10 weeks. 16S rRNA gene sequencing showed that cadmium exposure perturbed gut microflora structure and richness at family and genus level. The abstract says the microbiome change might raise serum lipopolysaccharide and hepatic inflammation, and might indirectly perturb energy homeostasis.
This page records that bibliographic identity and those abstract statements. It does not set a food concentration or a certification limit.
Evidence fitness
Supports a mouse finding that subchronic drinking-water cadmium changes gut microbiome composition alongside hepatic energy metabolism. Does not support a concentration of cadmium in any food.
Related evidence
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