Giambo and colleagues reviewed PubMed articles from the five years before 2020 on toxic metals and gut microbiota. The WikiBiome corpus note states that reported microbiota changes are not homogeneous across studies, and it summarizes the screened literature metal by metal.
Key numbers
The note states that 600 articles were screened and 97 were selected. For arsenic, it states that human studies of 204 infants in the United States associated arsenic with 15 genera, including Bacteroidetes and Bifidobacterium. For mercury, it states that methylation and demethylation are a core process in methylmercury metabolism and that microbiota changes have been linked to neurodevelopmental effects in rat offspring. For manganese, it states sex-specific effects and that fecal microbiota transplant can lessen manganese neurological toxicity. For copper, it states that excess copper alters microbiota and causes histopathological lesions in liver and intestines. The note does not assign a new sample size to the mercury, manganese, or copper summaries beyond the 97 included articles.
Evidence fitness
The record supports a review map of metal and gut microbiota studies. It does not support a concentration of any metal in food, and it does not state a limit. The 204-infant arsenic sentence points at a cohort already filed as Sex-specific associations of infants' gut microbiome with arsenic exposure.
Limitations
This page records the WikiBiome corpus note. It is not a new extraction from a local copy of the review. Metal-specific sentences in the note are summaries of other studies, not a new measurement.
Related evidence
Update history
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