Feng and colleagues randomized 152 occupational workers in Pakistan to yogurt with Pediococcus acidilactici GR-1 or to conventional yogurt for 12 weeks. The WikiBiome corpus note states that blood copper and blood nickel fell more in the probiotic arm, fecal copper and nickel rose, and Blautia species increased.
Key numbers
The note states n = 152, with 76 participants in each arm. In the probiotic arm, blood copper fell 34.45 percent, from 1,246 ± 20.7 to 817 ± 145.1 µg/L (p < 0.0001), and blood nickel fell 38.34 percent, from 4.855 ± 3.392 to 2.994 ± 1.942 µg/L (p < 0.0001). The conventional yogurt arm fell 16.41 percent for copper and 27.57 percent for nickel. Fecal acetate (p = 0.0322), propionate (p = 0.0061), and butyrate (p = 0.0469) increased in the probiotic arm versus baseline. The note states that most enriched gut species correlated negatively with blood copper. The trial registration in the note is ChiCTR2100053222.
Evidence fitness
The record supports a human trial finding about occupational copper and nickel, a probiotic yogurt, and gut microbiota. It does not support a concentration of copper or nickel in a retail food, and it does not state a limit.
Limitations
This page records the WikiBiome corpus note. It is not a new extraction from a local copy of the paper. The workers were occupationally exposed. The note does not report a dietary food concentration.
Related evidence
Update history
No substantive edit history is available in this build. The full commit record is available in git.