Dahan and colleagues exposed larval zebrafish to arsenic in water for 20 days and sequenced the 16S rRNA gene. The WikiBiome corpus note states that 10 ppb arsenic altered overall microbial composition, and that 100 ppb increased a class 1 integron.
Key numbers
The note states exposures of 10, 50, and 100 ppb arsenic for 20 days. Arsenic exposure explained 54.7 percent of the variance in overall bacterial composition. Shannon diversity decreased by 1.2 times from 0 to 50 ppb and increased by 1.1 times at 100 ppb (F(2,15) = 4.32, P = 0.03). ANOSIM R = 0.784 (P = 0.01). The class 1 integron relative copy number was 9 times higher at the highest concentration than in controls (F(2,14) = 13.27, P < 0.01). The note does not give the number of larvae, and it does not state whether the dissolved arsenic was inorganic or total.
Evidence fitness
The record supports a larval zebrafish water-exposure finding about arsenic and the microbiome. It does not support a concentration of arsenic in any food, and it does not state a limit.
Limitations
This page records the WikiBiome corpus note. It is not a new extraction from a local copy of the paper. The model is larval zebrafish, not a human gut sample. The note flags that the finding needs validation in a mammalian gut.
Related evidence
Update history
No substantive edit history is available in this build. The full commit record is available in git.