Relationship of prenatal methylmercury

Overview

This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.

Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

• (-0.0085 95% (-0.0167; -0.0003) per MeHg µg/L maternal blood (based on eight studies)). Results of a fill and trim
• approximately 3% of the U.S. population has MeHg blood The approach is summarized briefly here (see inclusion/
• concentrations above 5.8 µg/L, the concentration cor- exclusion criteria specified for populations, exposures,
• Agency) recommended limit to prevent harmful health Table 1). The literature search covered the period of Janu-
• on tests that were similarly normed (e.g., mean 100 and rating were then evaluated for other study domains. In
• yses specified in PECO criteria in Supplemental Table 1). were then converted to the common maternal blood bio-
• fidence were considered for these meta-analyses, as any (1.7 for the ratio of µg/L MeHg in cord blood to µg/L
• latter study (25), however, provided scores for another tion. The rest (N = 12) were rated as medium confidence.
• Fundamentals, fifth edition (CELF-5 (26)), which were provided in Table 1 and Supplemental Table 2. For the
• included in the meta-analysis of the normed tests (mean BNT without cues (Fig. 1 top), the meta-estimate was not
• 100 and SD 15). The remaining excluded studies are as statistically significant (−0.016 (−0.056; 0.023) per µg/L of
• eral language/verbal tests, three (8, 28, 29) that used sub- geneity was significant (p = 0.008) and I2 was 77%. Egger’s
• tests that are not normed to a mean of 100 and SD of 15, test for publication bias was not significant (p = 0.92).
• subtest (mean 50 and SD 10) were excluded as well. beta (−0.011 (−0.036, 0.014) per µg/L of maternal blood
• In some cases, the effect estimates extracted from the cant (−0.033 (−0.074, 0.007) per µg/L of maternal blood
• measures using different bases (2, e, 10). Using method- and p = 0.15), and I2 was 25%.
• the results that would have been obtained without log- −0.0003) per µg/L of maternal blood MeHg) with
• Table 1 Demographic, biomarker, and modeling results (re-expressed and converted to maternal blood) for BNT and language/verbal
• cation bias (p = 0.059). After using the trim and fill pro- meta-estimate (–0.0067 (−0.014, 0.003) per MeHg µg/L
• (−0.0082 (−0.16,0) per MeHg µg/L maternal blood), but from the PHIME cohort (46, 47) or replacing one study
• (−0.377, 0.046) per MeHg µg/L maternal blood). The lat- specific quantitative analyses (only two studies present
• former larger study are included in the main analysis. portions of each sex were close to 50%). Nevertheless, the
• (−0.38, 0.12) per MeHg µg/L maternal blood. Results of compared with girls (40, 44). More sex-specific data is
• −0.0002) per MeHg µg/L maternal blood. results for total mercury (THg) as a surrogate of MeHg

Methods (brief)

• Analytical method details were not mechanically resolved from extracted text.

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

• Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
• Shellfish (shrimp, crab, lobster, clams, oysters, mussels)
• Mercury
• Mercury
• Lead

Verification notes

• Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing wiki/sources/ pages before creation.
• Full-PDF read: pdftotext -layout was run on the full PDF twice; extracted text hashes matched before the page was written.
• Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
• Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
• HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.