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Unmarked glass laboratory vessels, a closed notebook, sampling spoon and empty specimen dish illustrating Barbosa 2018 toxicology source research context.

Toxicology © Elsevier after peer review. To access the final edited and published

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Overview

This source page is a mechanical bulk-ingest record for a PDF in the methylmercury infant-formula research pull. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.

Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

  • Vera Barbosaa,c, Ana Luísa Maulvaulta,b,c, Ricardo N. Alvesa,1, Christian Kwadijkd, Michiel
  • 9 Cunhaj, António Marquesa,c*
  • 13 Atmosphere, I.P. (IPMA), Lisboa, Portugal
  • 17 (FCUL), Lisboa, Portugal
  • 32 National Food Institute, Technical University of Denmark, Kgs Lyngby, Denmark
  • 34 Institute for Agricultural and Fisheries Research (ILVO), Ostend, Belgium
  • 36 Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat
  • 38 Rovira i Virgili, Reus, Catalonia, Spain
  • 40 LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University
  • 42 of Porto, Porto, Portugal
  • 46 António Marques
  • 52 Avenida de Brasília, 1449-006 Lisboa, Portugal.
  • 59 Current address: King Abdullah University of Science and Technology (KAUST), Red Sea Research
  • 60 Center (RSRC), Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • 3 A.L. Maulvault: aluisa@ipma.pt
  • 5 R.N. Alves: ricardo.alves@ipma.pt
  • 10 A. Tediosi: alice.tediosi@aeiforia.eu
  • 17 R. R. Rasmussen: riro@food.dtu.dk
  • 22 L. Trabalón: laura.trabalon@urv.cat
  • 37 hexamethyl-1,2,3,4-tetrahydronaphthalene; ANOVA - analysis of variance; AsV – arsenic V;
  • 39 BaP - benzo(a)pyrene;BMDL - benchmark dose lower limit; BP1 - Benzophenone 1; cadmium (Cd) -
  • 41 cadmium; CeCs - contaminants of emerging concern; chromium (Cr) - chromium; Cr – chromium; Cu -
  • 47 muscle reference material; DPMI - 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone; dSPE -
  • 49 dispersive solid-phase extraction; EC – European Commission; ECHA – European chemicals
  • 51 agency ; EFSA – European Food Safety Authority; EHS - 2-Ethylhexyl salicylate; EPA -
  • 53 eicosapentaenoic aci; ERM-BC211 – rice reference material; GC–IT-MS/MS - gas
  • 55 chromatography-ion trap-tandem mass spectrometr; GC-MS - gas chromatography-mass
  • 57 spectrometry; HBGVs - health-based guidance values; mercury (Hg) – mercury; HHCB - 1,3,4,6,7,8-
  • 2 performance liquid chromatography; HS - 3,3,5-Trimethylcyclohexylsalicylate; inorganic arsenic (iAs) - inorganic
  • 4 arsenic; ICP-MS - inductively coupled plasma mass spectrometer; ISTD – internal standards;
  • 8 mass spectrometry; LOD - limit of detection; LOQ - limit of quantification; methylmercury (MeHg) – methyl
  • 10 mercury; MOE – margins of exposure; MS- mass spectrometry; NOAEL – no observed adverse
  • 12 effect level; OC – Octocrylene; PAH2 - sum of benzo(a)pyrene, chrysene; PAH4 - sum of
  • 18 dibenzo(a,h)anthracene, indeno(123cd)pyrene, benzo(ghi)perylene; PAHs - polycyclic aromatic
  • 20 hydrocarbons; PAHs - polycyclic aromatic hydrocarbons; lead (Pb) – lead; PCBs - polychlorinated
  • 22 biphenyls; PCPs - personal care products; PFBA – perfluorobutanoate; PFBS - perfluorobutane
  • 34 perfluorotridecanoate; PFUnA - perfluorundecanoate; POPs - persistent organic pollutants;
  • 36 QuEChERS - quick, easy, effective, rugged and safe; RSD - relative standard deviation; TAs -
  • 38 total arsenic; TDI - tolerable daily intake; THg - total mercury; TORT-2 - lobster hepatopancreas
  • 40 reference material; TWI - tolerable weekly intake; UF - safety/uncertainty factor; UL - tolerable
  • 42 upper intake level; WHO – World Health Organization;
  • 2 Seafood consumption is a major route of human exposure to environmental contaminants of

Methods (brief)

  • hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-benzopyran-1-one; HPLC - high
  • 4 arsenic; ICP-MS - inductively coupled plasma mass spectrometer; ISTD – internal standards;
  • 8 mass spectrometry; LOD - limit of detection; LOQ - limit of quantification; MeHg – methyl
  • 10 mercury; MOE – margins of exposure; MS- mass spectrometry; NOAEL – no observed adverse
  • 4 were collected from different markets, including sole (Solea sp.), mackerel (Scomber
  • 14 For fish, muscle tissue (fillets) were collected without skin, while for cephalopods and
  • 16 crustaceans mantle and abdominal muscle tissue were sampled (n = 25). For bivalves, the
  • 18 edible part with the intervalvar liquid was collected (n = 50). Each sample was divided in two
  • 24 assessment. Raw and steamed samples were homogenized with a grinder (Retasch Grindomix
  • 35 Mercury concentrations (total and MeHg) were quantified by atomic absorption spectrometry,
  • 39 For total Hg determination, 10-20 mg of solid sample was placed on a sample boat of the
  • 41 automatic analyser. After drying and combustion, samples enter in a decomposition tube, where
  • 47 150 mg of freeze-dried samples were hydrolyzed in hydrobromic acid (10 mL, 47% w/w, Merck),
  • 53 sulfate and 0.775% sodium acetate, SIGMA). Then 100 µL of liquid sample (cysteine extracts
  • 8 Inorganic arsenic was quantified by anion exchange HPLC (High Performance Liquid
  • 10 Chromatography) (1260 HPLC Agilent Technologies, Waldbronn, Germany) coupled on-line to
  • 12 an ICP-MS, according to Rasmussen et al. (2012). Freeze-dried samples were weighed (0.2 -
  • 24 polytetrafluoroethylene filters in Mini-UniPrep HPLC vials (Whatman International, Maidstone,

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Update history

No substantive edit history is available in this build. The full commit record is available in git.

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