Summary
The EFSA CONTAM Panel Scientific Opinion on Mercury and Methylmercury in Food (December 2012, EFSA Journal 2012;10(12):2985) re-evaluated the prior JECFA tolerable weekly intakes for inorganic mercury (4 µg/kg b.w./week) and methylmercury (1.6 µg/kg b.w./week) in light of new epidemiological evidence. The Panel maintained the inorganic mercury TWI at 4 µg/kg b.w./week, expressed as Hg, but lowered the methylmercury TWI to 1.3 µg/kg b.w./week, expressed as Hg. The methylmercury revision was driven by Faroe Islands and Seychelles cohort data, with adjustment for the protective n-3 long-chain polyunsaturated fatty acid coefficients in fish. Mean dietary methylmercury exposure across European age groups does not exceed the TWI except for toddlers and other children in some surveys; 95th-percentile dietary exposure is close to or above the TWI for all age groups. High fish consumers can substantially exceed the TWI.
Key numbers
| Parameter | Value |
|---|---|
| TWI for inorganic mercury (maintained from JECFA) | 4 µg Hg/kg b.w./week |
| TWI for methylmercury (lowered from 1.6) | 1.3 µg Hg/kg b.w./week |
| Critical endpoint, methylmercury | Developmental neurotoxicity (in utero through maternal seafood) |
| Critical endpoint, inorganic mercury | Renal effects |
| Adjustment introduced | Protective coefficient for n-3 long-chain polyunsaturated fatty acids in fish |
| Population most exposed | High fish consumers; toddlers and children at 95th percentile |
Wiki pages updated on ingest
- Mercury
- EFSA — Inorganic Mercury Tolerable Weekly Intake (4 µg/kg b.w./week)
- EFSA — Methylmercury Tolerable Weekly Intake (1.3 µg/kg b.w./week)
Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.
| Commit | Date | Change | Description |
|---|---|---|---|
| a8052bb | 2026-08-09 | major | 4 sections added; narrative text revised |