In vitro study of Sb(III) oxidation. Knockout of anoA decreased oxidation efficiency by about 30 percent (PDF p.2). A separate sentence prints about 30 percent sequence similarity of AnoA with other oxidoreductases. Those are different 30 percent figures.
Key numbers
Growth was unaffected at 50 µM Sb(III). At 100 and 200 µM, katA, anoA, and aioA were required for resistance. Cellular hydrogen peroxide also oxidized Sb(III), with R2 0.93 in vivo and 0.94 in vitro. Genes for Sb(V) reduction and Sb methylation had not been identified.
Methods (brief)
Gene knockout in one environmental strain.
Evidence fitness
Supports the in vitro oxidation results. Does not support an effect in an infant gut or on skin.
Limitations
Evidence strength is in vitro.
Related evidence
Update history
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