Overview
This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.
Key numbers
The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:
- potency, in most of the comparisons (91%) with maternal hair MeHg estimates for the same
- was a 75% increase in sensitivity (range: 4–583%). In the two domains where results for maternal
- hair Hg were more sensitive, the rise was only 18% (Range: 7–29%). There were limited data
- more sensitive (mean 320% and range 43–855%) and cord blood biomarkers (maternal blood Hg
- was more sensitive by approximately 30%). Maternal hair Hg remains an appropriate biomarker
- approximately 3% of the U.S. population is exposed to MeHg at concentrations above U.S.
- exposures, comparators, outcomes (PECO) criteria (Supplemental Table S2) that provide
- presented in Supplemental Materials, Supplemental Tables S3 and S4. Briefly, included
- met or exceeded the following criteria: >50% of the samples were above the LOD; sample
- same subjects that were studied in other papers, leaving 5 studies for the analysis (Table 1).
- estimate) in 32 out of 35 comparisons (Table 2). Further, when cord blood Hg modeling
- (mean 75%; range 4–583%) than in the cases where maternal hair Hg results showed larger
- biomarker sensitivity (mean 43%; range 20–72% range) was greater than for the maternal
- right panel). Figures 2–4 demonstrate the rest of the comparisons. Supplemental Table S1
- reflect late gestational exposure (Table 1). The single investigation that collected hair in the
- mean 320%; range 43%−855%, based upon 7 comparisons (unadjusted comparison only
- and maternal blood Hg (maternal blood Hg more sensitive: mean 36%, range 15%−71%)
- based upon 10 comparisons, and in two comparisons, cord blood Hg was more sensitive (3%
- were not shown. At the exposure levels in studies analyzed here (Table 1), THg was found to
- may be 20–25%. However, that analysis does not inform the direction of possible bias
- Wells EM, Kopylev L, Nachman R, Radke EG, and Segal D. 2020. “Seafood, Wine, Rice, Vegetables,
- Snoj Tratnik et al. (2017) Croatia, Slovenia 361 1.5 GM 2.05 95% CI 2.05 GM 0.36 95% CI 34 week or birth 1–3 cm closest to scalp BSID III
- Valent et al. (2013) Italy 606 1.5 Mean (SD) 5.54 (4.83) Mean (SD) 1.06 (1.03) 20–22 week 1 gram BSID III
- Barbone et al. (2019) Croatia, Greece, 1200 1.5 Mean (SD) 5.51 (5.0) Mean (SD) 1.0 (1.0) From 20 week to Varies from 1–3 cm to 1 gram, BSID III
- (used same subjects as Slovenia, Italy Range 0.1–39.6 Range 0.017–13.5 birth close to scalp
- Abbreviations/References: GM – geometric mean, SD – standard deviation, CI – confidence interval, IQR – inter-quartile range (25%−75%), BAEP – Brain stem auditory evoked potentials (Araki and
- because table 2 includes subtests, whereas table 1 does not. Budtz-Jørgensen et al. (1999) applied 4 different statistical models but here only the best Kopylev et al.
- Overall 32 (35) 4–583% (75%; 44%) 7–29% (18%; 18%)
Methods (brief)
- biomarkers of MeHg exposure in samples of maternal hair and blood, and cord blood. The
- blood samples (NRC 2000). Because different cohorts have relied on different biomarkers
- risks of DNT effects of MeHg, using data from investigations that collected more than one
- from the Faroe Islands collected more than one biomarker, and these authors continued
- met or exceeded the following criteria: >50% of the samples were above the LOD; sample
- collection procedures were described, and for hair samples, the description included the
- site on the body and distance from that site where hair was cut; at no point during sample
- collection, preparation, or analysis did the samples exceed a temperature of 65°C potentially
- resulting in loss of sample analyte such as hair sample washing and drying, or open-vessel
- sample digestion. In addition, to attain a rating of adequate or higher, studies using standard
- In the studies considered in this analysis, maternal hair was collected most frequently at
- reflect late gestational exposure (Table 1). The single investigation that collected hair in the
- levels are generally less variable for cord blood samples (e.g., smaller coefficient of variation
- for replicate samples) than these are for maternal hair samples due to factors specific to
Implications
This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.
Wiki pages this source may touch
- Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
- Shellfish (shrimp, crab, lobster, clams, oysters, mussels)
- Mercury
- Mercury
Verification notes
- Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing
wiki/sources/pages before creation. - Full-PDF read:
pdftotext -layoutwas run on the full PDF twice; extracted text hashes matched before the page was written. - Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
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- HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.
Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.