Eggers and colleagues analyzed the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort in Mexico City. The abstract states that this pilot analysis included 123 children, 74 male and 49 female. Prenatal lead was measured in maternal whole blood in the second and third trimesters. Stool collected at ages 9 to 11 was sequenced by metagenomics.
The abstract states that the analysis suggests a consistent negative relationship between prenatal maternal blood lead and the gut microbiome at ages 9 to 11, including alpha and beta diversity, a microbiome mixture analysis, and individual taxa. Mean prenatal maternal blood lead was 33.6 µg/L (standard error 2.1) in the second trimester and 34.9 µg/L (standard error 2.1) in the third trimester. Weighted quantile sum regression showed a negative association for both trimesters (second trimester beta -0.17, 95 percent confidence interval -0.46 to 0.11; third trimester beta -0.17, 95 percent confidence interval -0.44 to 0.10). Ruminococcus gnavus, Bifidobacterium longum, Alistipes indistinctus, Bacteroides caccae, and Bifidobacterium bifidum had weights above the importance threshold in 80 percent or more of the repeated holdouts for both trimesters. The abstract says additional investigation is needed.
This page records that bibliographic identity and those abstract statements. It does not set a food concentration or a certification limit.
Evidence fitness
Supports a pilot human association between prenatal blood lead and the childhood gut microbiome. Does not support a concentration of lead in any food.
Related evidence
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