Coryell and colleagues tested whether the gut microbiome is required for full protection against acute inorganic arsenate toxicity in mice. Antibiotic-treated and germ-free mice excreted less arsenic in stool and accumulated more arsenic in organs than controls. Human stool transplants from five donors protected germ-free mice that lack As3mt from arsenic-induced mortality, and that protection differed by donor.
Key numbers
The WikiBiome corpus note states p < 0.0001 at 25 ppm inorganic arsenate, and p = 0.025 at 100 ppm, for lower fecal excretion and higher organ accumulation after cefoperazone. Germ-free As3mt-knockout mice had lower survival than sham-treated As3mt-knockout mice at both 25 ppm and 100 ppm (p < 0.0001). Humanized germ-free As3mt-knockout mice survived longer than conventional germ-free As3mt-knockout mice (p < 0.0014) across 5 human donors. Shannon and inverse Simpson diversity correlated with longer survival (p = 0.0447 and p = 0.0155). Escherichia coli plus Faecalibacterium increased survival compared with Escherichia coli alone (p = 0.0035). The note does not give a single mouse count.
Evidence fitness
The record supports a mouse finding about inorganic arsenate and the gut microbiome. It does not support a concentration of arsenic in any food, and it does not state a limit.
Limitations
This page records the WikiBiome corpus note. It is not a new extraction from a local copy of the paper. Group sizes for the mice are not in that note.
Related evidence
Update history
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