Overview
This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.
Key numbers
The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:
- seafood consumption increased Hg contents in fetal tissues and resulted in ~34% of cord blood
- samples exceeding the EPA Hg reference level of 5.8 ppb (0.029 μM). However, Se concentrations
- depletes liver, muscle, and blood Se contents to ~ 2% of normal (Prohaska and Ganther,
- to maintain brain Se at ~60% of normal in their offspring (Behne et al., 2000) and thus
- (Environmental Express) for 24 hours. Samples were cooled, then 1.5 mL of 30% H2O2
- alongside samples in all batches. The certified values and expected ranges for Hg (14.7
- ± 2.2 μg/kg) and Se (214 ±32 μg/kg) for UTAK 2 coincided well with the observed values:
- groups based on maternal fish consumption levels as shown in Table 1. To conform with the
- samples (Figure 2). The Benchmark Dose lower confidence limit (BMDL) level of 58 ppb
- 5.8 ppb (~0.029 μM) corresponding to the US EPA 0.1 μg Hg/kg/bw reference dose (RfD)
- in cord blood Hg relative to Se and resulted in ~34% of cord blood samples in this cohort
- exceeding the EPA reference level of 5.8 ppb (0.029 μM), even the highest level of Hg
- Hg/day, resulted in ~85% of their total Hg exposures with only ~15% arising from ocean fish
- (Ralston et al., 2015). However, the ocean fish they ate provided over 80% of their total Se
- Hg (58 ppb ≈ 0.29 μM) was based on data (Budtz-Jorgensen et al., 2000) which omitted
- notable sources of omega-3 fatty acids and other nutrients is associated with substantial
- benchmark dose lower confidence limit (BMDL = 58 ppb, ≈ 0.29 μM) established using
- = 5.8 ppb, (≈ 0.029 μM) associated with the US EPA Hg RfD of 0.1 μg/kg-bw/d after
- (12+oz/wk) ocean fish intakes. Means and standard deviations are shown. Statistically significant differences (p<0.05) as established by unpaired
Methods (brief)
- samples were collected following delivery of a cohort of 100 babies born on Oahu, Hawaii.
- samples exceeding the EPA Hg reference level of 5.8 ppb (0.029 μM). However, Se concentrations
- 2.2. Sample Collection
- A whole blood sample (~14 mL in standard EDTA anticoagulated vacutainer) was collected
- stored at −25°C until shipping for elemental analysis. Placental tissue samples were
- collected from regions proximal and peripheral to the umbilical cord within 2 hours of
- Umbilical cord blood and placental tissue samples were shipped to the University of North
- Dakota for elemental analysis. Individual (~0.25 g) samples of blood and placental tissue
- were weighed into single-use, trace element-free 50-mL digestion tubes (Environmental
- Express, Mt. Pleasant, SC) prepared in a series of digestion sets along with analysis
- blanks, certified reference materials (UTAK) and quality control samples. Samples (and
- (Environmental Express) for 24 hours. Samples were cooled, then 1.5 mL of 30% H2O2
- 85°C for 8 hours. Samples were cooled, treated with 15 mL of 12 N HCl (Fisher Trace
- Samples were cooled and diluted to 25 mL with double-distilled water. Digested and diluted
- samples were analyzed for total Hg by cold-vapor atomic absorption spectrophotometry
- hydride generation atomic absorption spectroscopy using a PS Analytical Dual Millennium
- alongside samples in all batches. The certified values and expected ranges for Hg (14.7
- the data from each digestion batch were qualified for inclusion in the database. Mass
Implications
This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.
Wiki pages this source may touch
- Fish — marine, predatory (tuna, swordfish, shark, king mackerel)
- Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
- Shellfish (shrimp, crab, lobster, clams, oysters, mussels)
- Mercury
- Mercury
- Cadmium
- Arsenic
Verification notes
- Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing
wiki/sources/pages before creation. - Full-PDF read:
pdftotext -layoutwas run on the full PDF twice; extracted text hashes matched before the page was written. - Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
- Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
- HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.
Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.