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Prescription Infant Formulas Are Contaminated with Aluminium
International Journal of Environmental Research and Public Health 16(5):899
Year
2019
Authors
James Redgrove; Isabel Rodriguez; Subramanian Mahadevan-Bava; Christopher Exley
Source type
peer reviewed
License
cc by
Redgrove, Rodriguez, Mahadevan-Bava, Exley 2019 — Prescription infant formulas are contaminated with aluminium
This International Journal of Environmental Research and Public Health article from the Birchall Centre at Keele University and Russells Hall Hospital, Dudley, is the first systematic survey of aluminium in prescription infant formulas. Twenty-four specialised UK formulas (ready-to-drink and powdered) were obtained from a paediatric clinic and analysed by transversely heated graphite furnace atomic absorption spectrometry (TH GFAAS) following microwave-assisted acid/peroxide digestion. The headline finding: ready-to-drink concentrations range from 49.9 µg/L in a preterm ready-to-drink formula to 1956.3 µg/L in an apple-flavoured ready-to-drink weight-gain supplement, a roughly 40-fold range. The highest-Al product delivers 391.3 µg Al per 200 mL serving. Some prescription formulas, including two amino-acid powders prepared according to manufacturer instructions at 41.4 and 44.4 µg/L, were the lowest-Al formulas measured in the Keele group’s accumulated experience, demonstrating that the contamination of infant formulas with aluminium is not inevitable. Powdered formulas were generally less contaminated than ready-to-drink products, which inverts the pattern seen for off-the-shelf formulas in their prior work.
Key numbers
Ready-to-drink formulas for preterm/IUGR infants (Table 1, n=5 measurements per product)
Product descriptor
[Al] µg/L mean (SD)
Al µg/serving (volume)
Preterm ready-to-drink formula, 70 mL serving
49.9 (33.7)
3.5 (70 mL)
Preterm ready-to-drink formula, 200 mL serving
139.3 (143.6)
27.9 (200 mL)
Hydrolysed preterm/IUGR ready-to-drink formula
167.1 (10.6)
15.0 (90 mL)
Peptide-based high-energy ready-to-drink formula
228.5 (48.3)
45.7 (200 mL)
First-infant ready-to-drink formula, 70 mL serving
249.4 (64.0)
17.5 (70 mL)
Ready-to-drink formulas as supplements for weight gain (Table 2)
Powdered formulas for allergies and intolerance (Table 3)
Product descriptor
[Al] µg/g mean (SD)
Al µg/day (birth/6mo)
Allergy/intolerance powder, product 1
3.27 (0.19)
231/367
Allergy/intolerance powder, product 2
1.65 (0.76)
na/na
Allergy/intolerance powder, product 3
1.48 (0.24)
na/na
Lactose-free powder
1.07 (0.15)
77/106
Allergy/intolerance powder, product 4
0.53 (0.40)
35/59
Allergy/intolerance powder, product 5
0.46 (0.14)
53/69
Allergy/intolerance powder, product 6
0.35 (0.03)
26/47
Powdered formulas with additional amino acids (Table 4)
Product descriptor
[Al] µg/g mean (SD)
Al µg/day (birth/6mo)
Amino-acid powder, product 1
2.23 (1.23)
167/256
Amino-acid powder, product 2
0.61 (0.11)
na/na
Amino-acid powder, product 3
0.29 (0.12)
24/47
Amino-acid powder, product 4
0.27 (0.04)
21/24
Cross-formula synthesis (Table 5)
The full 24-product distribution as prepared per manufacturer instructions ranges from 41.4 µg/L (the lowest-Al amino-acid powder in the Keele group’s accumulated literature) to over 1900 µg/L (the highest-Al apple-flavoured ready-to-drink weight-gain supplement). Powdered formulas were generally lower than ready-to-drink products. The 40x range across this small dataset establishes both that high-Al contamination is common in prescription infant formulas and that low-Al formulas are technically achievable.
Methods (brief)
Twenty-four prescription infant formulas obtained pristine and unopened from the Paediatric Clinic of Russells Hall Hospital, Dudley, UK. Each product mixed manually before sampling. Total Al measured by transversely heated graphite furnace atomic absorption spectrometry (TH GFAAS) following microwave-assisted acid/peroxide digestion. n=5 per product. Analytical methods and quality-assurance data were stated to be identical to the authors’ previous laboratory methods cited as references 1, 2, and 9. Comparison provided across ready-to-drink and powdered formulations (Table 5).
Implications
Certification: Primary occurrence evidence that prescription infant formulas can span a roughly 40-fold Al range by format and product type. The page supports source-level product-format stratification, not a certification threshold proposal.
Microbiome / clinical: Vulnerable population (preterm and IUGR infants, infants with allergies, infants requiring amino-acid-based or peptide-based formulas) is exposed via a single feeding modality and cannot diversify exposure. No safety margin via dietary variation.
App: Powder vs ready-to-drink Al differential is a relevant stratification variable. Fruit-flavoured ready-to-drink weight-gain supplements are an outlier category in this dataset.
Courses: Foundational primary occurrence-data reference for infant formula Al.
Cross-vendor audit (Codex, 2026-05-17) removed sampled-product brand names under the locked strict Part 12 reading, corrected the stale raw PDF path, replaced nonstandard matrix terms with controlled vocabulary, removed an unsupported soy-based product route, and corrected the methods citation summary.
Brand names are present in the source tables, but this source page intentionally uses product-form descriptors only because no public-record regulatory event exception applies.
Page history
The five most recent substantive edits to this page. The full version history lives in git; when DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.