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Heavy Metal Index

Bioaccessibility of Heavy Metals in Raw and Processed Alternanthera sessilis and Centella asiatica: An In vitro Study

This Sri Lankan study compares elemental concentrations and simulated digestive release in two leafy vegetables across five growing areas.

This Sri Lankan study compares elemental concentrations and simulated digestive release in two leafy vegetables across five growing areas. Raw, coconut-milk-cooked and coconut-oil-stir-fried portions were tested separately; lower in-vitro release does not establish lower human absorption or safe consumption.

Key numbers

Total plant content, mg/kg, with source ± dispersion:

SpeciesAreaMetalTotal
Alternanthera sessilisPiliyandalaNi3.02±1.02
Alternanthera sessilisPiliyandalaCd0.20±0.01
Alternanthera sessilisPiliyandalaCr0.82±0.20
Alternanthera sessilisPiliyandalaPb0.24±0.04
Alternanthera sessilisPiliyandalaCu7.85±2.21
Alternanthera sessilisWellampitiyaNi8.42±2.25
Alternanthera sessilisWellampitiyaCd0.36±0.06
Alternanthera sessilisWellampitiyaCr4.59±1.11
Alternanthera sessilisWellampitiyaPb3.14±0.98
Alternanthera sessilisWellampitiyaCu15.40±3.23
Alternanthera sessilisKolonnawaNi11.35±2.76
Alternanthera sessilisKolonnawaCd0.86±0.04
Alternanthera sessilisKolonnawaCr6.74±2.22
Alternanthera sessilisKolonnawaPb3.05±1.01
Alternanthera sessilisKolonnawaCu10.30±2.99
Alternanthera sessilisKottawaNi9.15±1.87
Alternanthera sessilisKottawaCd0.22±0.05
Alternanthera sessilisKottawaCr5.05±1.23
Alternanthera sessilisKottawaPb3.89±1.00
Alternanthera sessilisKottawaCu10.90±2.45
Alternanthera sessilisBandaragamaNi2.02±0.98
Alternanthera sessilisBandaragamaCd0.11±0.01
Alternanthera sessilisBandaragamaCr0.78±0.07
Alternanthera sessilisBandaragamaPb0.31±0.05
Alternanthera sessilisBandaragamaCu6.96±1.45
Centella asiaticaPiliyandalaNi2.11±1.01
Centella asiaticaPiliyandalaCd0.15±0.05
Centella asiaticaPiliyandalaCr0.72±0.12
Centella asiaticaPiliyandalaPb0.27±0.09
Centella asiaticaPiliyandalaCu10.60±2.12
Centella asiaticaWellampitiyaNi14.06±3.12
Centella asiaticaWellampitiyaCd0.32±0.08
Centella asiaticaWellampitiyaCr5.82±2.03
Centella asiaticaWellampitiyaPb5.90±2.01
Centella asiaticaWellampitiyaCu16.26±5.21
Centella asiaticaKolonnawaNi16.55±5.25
Centella asiaticaKolonnawaCd0.45±0.11
Centella asiaticaKolonnawaCr11.33±2.31
Centella asiaticaKolonnawaPb10.23±1.98
Centella asiaticaKolonnawaCu21.22±6.86
Centella asiaticaKottawaNi11.23±2.45
Centella asiaticaKottawaCd0.30±0.08
Centella asiaticaKottawaCr4.36±2.00
Centella asiaticaKottawaPb3.21±1.98
Centella asiaticaKottawaCu16.22±5.43
Centella asiaticaBandaragamaNi1.45±0.98
Centella asiaticaBandaragamaCd0.15±0.07
Centella asiaticaBandaragamaCr0.63±0.12
Centella asiaticaBandaragamaPb0.30±0.12
Centella asiaticaBandaragamaCu5.32±0.57

Every gastric/intestinal concentration, percentage, dispersion and ND cell from Tables 1–2 is retained in the structured batch table. Overall gastric/intestinal bioaccessibility reported on p 8: Ni 9.98/3.51%, Cd 9.46/5.81%, Cr 3.93/1.97%, Pb 9.70/3.15%, Cu 13.8/33.6%; pooled denominators are not explicit.

Methods (brief)

80 samples across Piliyandala, Wellampitiya, Kolonnawa, Kottawa, Bandaragama. Each edible sample split into 200 g portions: raw; 50 mL coconut milk cooking; 15 mL coconut oil stir-frying, 12 minutes at 95±2°C. PBET at 37°C uses gastricpH 2.5 for 1 h and intestinalpH 7 for 2 h. ICP-OES; total analysis by AOAC 999.11 dry ashing. SpinachCRM recovery 96–104%; LODµg/g: Ni 0.025, Cd 0.005, Cr 0.010, Pb 0.050, Cu 0.015. Reported concentration moisture basis is not explicit.

Implications

Supports region-specific leafy-vegetable occurrence and cooking/bioaccessibility comparisons. Processing effects are not uniform: for example Wellampitiya A. sessilis gastric Pb is 15.3% raw and 20.7% cooked. Coconut additions can change the matrix; an in-vitro endpoint is not in-vivo absorption.

Evidence Fitness: EF-2 for source concentrations and region/treatment comparisons; EF-3 for modeled digestive exposure. Keep total plant results separate from digest fractions and preserve nondetection.

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Verification notes

Novel in-vitro-digest matrix represents PBET extracts, never a product concentration row. All 50 table rows and their 13 cells are preserved, with source ± treated as unspecified dispersion rather than inventing SD. Tables govern over prose ranges that occasionally disagree. Cr is elemental/unspeciated. WHO/FAO comparisons in table footers are not primary legal evidence. Duplicate/overlapping PDF text layers are counted once; no exact values invented for unlabeled Figure 3/4 bars.

The preserved Library PDF is identified by RPHMI_13; SHA-256 a3831d5e819ddfe322589009fb7273dc78310edbc80de2be5e22c9cd7a19ae0b. The byline, year and publication were verified in the PDF. DOI provenance and any publication-date differences are described above. Original access location: https://doi.org/10.46488/nept.2026.v25i01.d1830. Source-specific numeric observations, context dispositions, row-fit decisions and remaining gaps are preserved in the structured evidence record. No source value was converted across product, soil, water or experimental matrices during ingest.

Update history

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