This laboratory study used an aqueous fruit extract of Emblica officinalis (Indian gooseberry) to reduce selenium into nanoparticles, characterized them, and tested antioxidant, antimicrobial and cell toxicity effects. In a mouse neuroblastoma cell line the nanoparticles were far less cytotoxic than sodium selenite. The work does not measure selenium in diets or people.
Key numbers
- Cell viability, MTT assay in N2a cells: sodium selenite IC50 14.01 µg/mL and IC90 24.60 µg/mL; nanoparticles IC50 127.28 µg/mL and IC90 234.41 µg/mL (Results, p. 13).
- Particle diameter 15 to 40 nm by high-resolution electron microscopy (Abstract).
- This paper reports no numerical findings relevant to selenium dietary exposure.
Methods (brief)
Green synthesis with fruit extract; spectroscopic, diffraction and microscopy characterization; radical scavenging assays; antimicrobial tests against foodborne microbes; MTT and live/dead staining in one cell line.
Evidence fitness
Off-topic for dietary exposure. The paper does not support dietary exposure or toxicity claims; the cell-line comparison with selenite is mechanistic context only.
Limitations
Single cell line; in vitro concentrations cannot be translated to dietary doses; no in vivo testing.
Related evidence
Update history
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