D. J. Gawkrodger and colleagues measured nickel on occupational skin and tested a single open application of nickel on nickel-allergic volunteers, read at 2 days. The journal issue is 2012. The DOI year is the 2011 acceptance record. Doses below are micrograms per square centimetre. The microgram sign in the printed unit is damaged in this copy.
Key numbers
Table 2 grade counts (negative, doubtful, +, ++, +++):
| Dose (µg/cm2) | n | Negative | Doubtful | + | ++ | +++ |
|---|---|---|---|---|---|---|
| 0.05 | 2 | 2 | 0 | 0 | 0 | 0 |
| 0.5 | 2 | 2 | 0 | 0 | 0 | 0 |
| 2.5 | 3 | 3 | 0 | 0 | 0 | 0 |
| 5.0 | 21 | 15 | 5 | 1 | 0 | 0 |
| 15 | 19 | 13 | 3 | 1 | 2 | 0 |
| 30 | 19 | 12 | 2 | 2 | 3 | 0 |
| 45 | 18 | 7 | 6 | 2 | 2 | 1 |
The abstract counts six of 21 at 5.0 µg/cm2, six of 19 at 15, seven of 19 at 30, and eleven of 18 at 45. Those counts add the doubtful grade to the positive grades. Table 2 is the count of record. A QC solution certified at 58.1 µg/L nickel (NIES-1643d) measured 53.3 µg/L (RSD 1.1%, n = 5). Occupational finger means in Table 1 were not cleanly recovered and are not entered.
Methods (brief)
Open application on the forearm, read at 48 hours, ICDRG grades. ICP check of a certified nickel solution.
Evidence fitness
Table 2 supports the open-application dose response. It does not supply the occupation means.
Limitations
Occupation means in Table 1 are not readable as a complete table in this copy. The EU release limit is discussed, but a numeric release value is not printed in the prose used here.
Related evidence
Update history
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