Louise Arup Fischer, Torkil Menné, and Jeanne Duus Johansen review occluded nickel dose-response studies and fit a summary threshold. Eight studies were selected on statistical grounds. The DOI is the record that matches this title.
Key numbers
The authors’ analysis gives 0.44 mg Ni/cm2 as the dose to which 5% of a sensitized population react, and 1.04 mg Ni/cm2 as the dose to which 10% react, under occluded exposure. A comparison with open application is printed, but the dose multiplier in that sentence is not cleanly readable and is not recorded.
Methods (brief)
Statistical summary of published occluded patch studies. Not a new survey of products.
Evidence fitness
The two doses are the review’s own summary statistics. Individual study doses are not re-listed.
Limitations
Occluded exposure only. The open-application comparison is omitted because the dose multiplier in that sentence is not readable in this copy.
Related evidence
Update history
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