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Effects of Dietary Intake of Arsenosugars and Other Organic Arsenic Species on Studies of Arsenic Methylation Efficiency in Humans

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Overview

This source page is a mechanical bulk-ingest record for a PDF in the Heavy Metal Index raw corpus. It preserves source-level identity, routeable analyte and product scope, and the exact extracted numeric lines that justify that scope, for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.

Author, year, and title are taken from the Crossref record for the DOI, not scraped from the PDF text.

Key numbers

Each analyte named in metals: is listed below with the measurement-bearing lines that caused it to be asserted. Lines are copied from the verified extraction and retain the source units and wording where legible. An analyte with no lines here would not appear in the source metadata.

total arsenic (tAs)

  • 2022 report.1 Chronic exposure to inorganic arsenic is known inorganic arsenic metabolism, approaches of methylation
  • interindividual differences in arsenic metabolism.4−8 exposure on the accuracy of methylation efficiency estimations.
  • exposure.14−17 Arsenic methylation efficiency parameters Received: June 30, 2023
  • and that exposure to other forms of arsenic is negligible. This DMA is primarily excreted through urine unchanged.25
  • exposure to other forms of arsenic through the ingestion of day) in the Japanese diet.53 Based on available data, exposure
  • the amount of arsenic excreted and the identity of urinary vs 0.38 μg arsenic (As)/h. A total of 176.3 μg/L of arsenic (DMA
  • that the pattern of arsenic metabolites and efficiency of arsenic median for AsB concentrations was 10.2 vs 0.9 μg/L).54
  • concentrations of arsenic metabolites after specific changes in Figure 3 shows mean inorganic arsenic (iAs)%, MMA%, and DMA% in urine
  • excretion was between 20 and 40 h, urinary arsenic necessarily mean exposure to arsenosugars and arsenolipids.
  • of seafood exposure and (2) assumption of concurrent arsenic methylation efficiency.
  • Health 2016, 15 (1), 62. Original Arsenic Exposure Cohort after Water Quality Improvement.
  • (44) Jones, M. R.; Tellez-Plaza, M.; Vaidya, D.; Grau, M.; Arsenicals in Food in Aggregate Exposure to Arsenic. J. Environ. Sci.

iAs

  • 2022 report.1 Chronic exposure to inorganic arsenic is known inorganic arsenic metabolism, approaches of methylation
  • More Toxic than Arsenite in Chang Human Hepatocytes. Toxicol. (53) Yoshinaga, J.; Narukawa, T. Dietary Intake and Urinary
  • J. D.; Navas-Acien, A. Estimation of Inorganic Arsenic Exposure in (63) Le, X.-C.; Cullen, W. R.; Reimer, K. J. Human Urinary Arsenic

Methods (brief)

  • ABSTRACT: Extensive research has used dimethylarsinic acid (DMA) in urine as a marker
  • monomethylarsonic acid (MMA) and DMA and excrete these arsenic species into the urine.
  • However, DMA in urine not only comes from the methylation of inorganic arsenic but also
  • might have overlooked confounding factors that contribute to DMA in urine. Here we
  • methylated arsenicals, or the percentage of DMA in urine as markers of arsenic methylation
  • potential effect on the urinary concentrations of DMA.
  • ic acid (MMA) and dimethylarsinic acid (DMA).9−13
  • concentrations of individual arsenic species (DMA, MMA,
  • methylation cycle to form dimethylarsinic acid (DMAV). binding sites.28 Dheeman et al.28 proposed that As(GS)3 acted
  • Further reduction of DMAV and the addition of a third methyl as a substrate for enzymatic methylation and that AsIII was
  • DMA + MMA + iAs V + iAsIII
  • DMA + MMA + iAs V + iAs III
  • state. According to this model, DMAIII is the major product of intra- and intercellular mobility of these arsenic species is
  • DMAV. studies often rely on arsenic metabolites as a fingerprint of
  • arsenic metabolites MMAV, DMAV, MMAIII, and DMAIII in Calculation of Methylation Efficiency
  • Inorganic arsenicals and their metabolites have a wide range iAs + MMA + DMA) represented by an individual metabolite,
  • cells,37 and neurons.38 Inorganic arsenic metabolites and their step from MMA to DMA (Figure 2).
  • methylarsenicals MMAV and DMAV have lower toxicities than

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Update history

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