Coryell and colleagues report mouse experiments on acute arsenic toxicity. The abstract states that the microbiome protects mice from arsenic-induced mortality. Antibiotic-treated and germ-free mice excreted less arsenic in stool and accumulated more arsenic in organs than control mice. Mice lacking the primary arsenic detoxification enzyme As3mt were hypersensitive to arsenic after antibiotic treatment or when derived germ-free, compared with wild-type or conventional counterparts. Human stool transplants protected germ-free As3mt-knockout mice from arsenic-induced mortality, and that protection depended on microbiome stability and on specific bacteria, including Faecalibacterium.
This page records that bibliographic identity and those abstract statements. It does not set a food concentration or a certification limit.
Evidence fitness
Supports a mouse finding that gut microbiome status changes arsenic excretion, organ accumulation, and survival under the study’s acute exposure. Does not support a concentration of arsenic in any food.
Related evidence
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