This paper maps the organic preservative 2-methyl-4-isothiazolin-3-one in ex vivo human skin by time-of-flight secondary ion mass spectrometry. It reports no metal concentrations. numbers is empty.
Key numbers
This source does not report a metal concentration or a metal limit.
Methods (brief)
MI (95 percent) was diluted to 0.0175 M, stated as equivalent to 0.2 percent w/v diagnostic patch testing, and 20 uL was applied to 11 mm skin biopsies. Donors were two women, both 42 years, abdominal skin, Fitzpatrick type 2.
Detection and reporting: not a metal assay; background ion at m/z 116.0 discussed but no metal LOD
Basis: applied solution on ex vivo skin
Evidence fitness
This source can support: localization of methylisothiazolinone in stratum corneum and viable epidermis.
It cannot support: any metal occurrence, absorption fraction, or metal regulatory limit.
Limitations
No Pb, Cd, As, Hg, Ni, Cr, Co, Sb, Zn, Al, Sn, or other metal concentrations are measured or established. An EU rinse-off limit of 0.0015 percent MI and an LLNA EC3 of 0.4 percent are organic-allergen figures, not metals, and were not entered as metal rows. Codex is noted in the task as having processed this paper locally.
Related evidence
- No product or metal page is declared for this source. The batch report records the gap.
Update history
No substantive edit history is available in this build. The full commit record is available in git.