Overview
This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.
Key numbers
The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:
- the total mean volume of urine recovered was 44.7 (range 26.7-71.1) mL. NTA yielded a list
- analyte quality control (QC) solution was prepared at 1,000 μg/L in methanol and an
- internal standard solution of isotopically labelled compounds was prepared at 2,500 μg/L in
- internal standard solution were added to all samples, followed by 250 μL of 1% formic acid
- injected two additional times (n = 6 each during the batch), followed by a reinjection of the
- mobile phase (B) was methanol with the following time program: 10% B from 0-1 min,
- dd-MS2 scan (2e5, Table S1) so that MS2 scans, important data for aiding in the structural
- were evaluated for signal and retention time variability across multiple injections (n = 6
- for QC analytes, n = 44 for internal standards) as a measure of the method’s performance;
- correction were filtered out of the data set (see Table S2 for settings). Integrated peak
- ages of 5 and 21 months (median =10) (Table 1). We collected a total of 70 diapers, and
- We recovered a mean of 44.7 (range = 26.7–71.1) mL total urine across diapers soiled by
- each child, and a mean of 7.3 (range = 2.4–15.2) mL per diaper; no specimen was recovered
- for 3/70 diapers (4%). At pickup, no caregivers reported illness or a non-normal mood in
- with CV 0.02-0.47% (n = 6 for QC compounds and n = 44 for internal standards). Peak area
- For internal standards, peak area CV were 6.4-22.7% and 5/7 internal standards had peak
- area CV <20%. Mass accuracies for all compounds were within ±2.16 ppm at the beginning
- of the batch, with mass accuracies for 37/41 compounds within ±1 ppm; by the end of
- the 34 h sequence mass accuracies were all within ±3.55 ppm, with mass accuracies for
- 22/41 compounds within ±2 ppm. When specimens were analyzed without an exclusion list,
- MS2 spectra increased to 75.8% (4536/5982).
- it should be noted that these two principal components only accounted for ~36% of the
- total variation in the data. Output from running the MLMM are given in the SI. Table 2
- applications in >80% of participants and the compounds were generally detected in multiple
- information on functional uses of these compounds can be found in Table S3.
- be suitable for a range of studies, even those in which analyses can be performed with ≤1
- the 70 diapers collected, most samples (64, 91.4%) were labeled by the caregiver as
- different research areas (Table 2). Ibuprofen (administered to participant 7) and penicillin
- industrial applications in a large percentage (>80%) of participants. Publicly available data
- Mean, range and total volume extracted were calculated using only soiled diapers (n=67)
- Penicillin V* 87-08-1 C16H18N2O5S 350.09364 99.6 1 (9.1%)
- Desmethylcitalopram 62498-67-3 C19H19FN2O 310.14814 95.6 1 (9.1%)
Methods (brief)
- All authors assisted with the design of the study and sample collection. SNL and KEN recruited all participants. QL prepared and
- processed all biological samples for analysis. MNN conducted non-targeted analysis and data analysis. SNL and MNN wrote the first
- volumes of recovered sample. This method was successfully implemented to recover urine from
- cotton pads collected in the field; between 5-9 diapers were collected per child in 24 hours, and
- especially if more than one sample is needed (14).
- of time to collect a sample, volume of sample collected) and ethical considerations (e.g.,
- non-targeted analyses of children’s urine collected with disposable diapers.
- chromatography–high-resolution mass spectrometry (LC-HRMS). The use of cotton pads
- settings. Caregivers of children were recruited, and children’s urine was collected in
- however, that this method, including sample preparation and data processing, can be tailored
- Six samples per diaper brand were prepared by placing a single cotton pad on top of the
- were centrifuged at 2,500 xg for 10 minutes. The specimen was collected in pre-weighed
- described above) six additional samples per diaper brand and stored them for 48 h at either
- total of 24 replicates). The syringe method was used to recover MQW from all 48 h samples,
- and samples for which MQW was successfully recovered were analyzed via LC-HRMS (see
- placed in disposable diapers for 24 h. All sample collection was completed between August
- Preparation of quality control samples
- A pooled QC specimen was prepared from each of the individual participant samples
Implications
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Verification notes
- Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing
wiki/sources/pages before creation. - Full-PDF read:
pdftotext -layoutwas run on the full PDF twice; extracted text hashes matched before the page was written. - Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
- Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
- HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.
Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.