international cohort study evaluating a

Overview

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Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

• Treatment (PREdiCT): protocol Almu’atasim Khamees ‍ ‍,45 David Beard,46,47 Catherine L Granger ‍ ‍,48,49 The
• Accepted 22 May 2026 preoperative interventions, thereby allowing equitable ⇒ Restriction to four languages (English, Spanish,
• that only 21% employed prehabilitation as standard of been selected based on indicators of feasibility including
• ⇒ Fondazione Policlinico Universitario, Rome, Italy screening tools across physical (n=21), nutritional (n=16)
• ⇒ San Raffaele Hospital, Milano, Italy and psychological (n=40) domains.19 Following this,
• screening tools across physical (n=3), nutritional (n=3)
• ⇒ Justus-­Liebig University, Giessen, Germany and psychological (n=4) domains. Selection of the final
• intake and function, with a maximal score of 36 points the Clavien-­Dindo Classification28 (see table 1); (3) major
• Table 1 The Clavien-­Dindo classification of postoperative complication severity
• based on the Clavien-­Dindo Classification (see table 1) surgical volume, cancer types treated, local resources and
• margin of error and 95% confidence level, the required key clinical confounders that are known to influence
• is 196. Considering a 95% response rate (as there is no factors, disease-­related factors and surgical factors.
• up) and typical 30% prevalence of postopera- Given the multicentre nature of this study, we will
• tive complications33 including 17% prevalence of major also account for potential centre-­level variation using
• acceptable discrimination and values ‍‍≥0.8 considered tion vs anastomotic leak) and (5) centre-­level variations
• tive effects between domain scores (eg, poor nutrition 1 point decrease below 34; 95% CI 1.00 to 1.09) and
• 1.03 per 1 point decrease below 34; 95% CI 1.01 to 1.05).36 able request, subject to ethics approval. A plain language
• Australia Catherine L Granger https://orcid.org/0000-0001-6169-370X

Methods (brief)

• ⇒ Maastricht University Medical Centre+, Maastricht, Netherlands utility for postoperative outcomes. For the purpose of this
• A range of secondary outcomes will be collected to from the PREdiCT screening tool may elicit uncomfort-
• be collected according to the standard process of the whether the PREdiCT screening tool, which includes
• Sample size calculation important patient subgroups.
• The sample size required has been calculated based on 1. Primary predictive analysis
• complications34 in the cohort, the required sample size is random effects or fixed effects as appropriate. We will
• Department of General Surgery, Maastricht University Medical Centre+, ORCID iDs
• Maastricht, The Netherlands Jack Reeves https://orcid.org/0009-0009-2851-5501
• depression severity measure. J Gen Intern Med 2001;16:606–13. 35 Hennink M, Kaiser BN. Sample sizes for saturation in qualitative

Implications

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Update history

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