Skip to content
Heavy Metal Index

uncovered numerous instances of its sensitivity to environmental influences; however, pinpointing specific mechanisms

Source

This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus.

Page snapshot
Cited by5 pages
Metals measured3
Evidence tierB
Year2025

Overview

This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.

Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

  • (Table 1) that demonstrate its utility as a tractable in vivo evolved eukaryotes remains a topic of debate.
  • Table 1 Select environmental epigenetic studies in C. elegans
  • Table 1 (continued)
  • transferases is under investigation. metazoan genome to be sequenced, with around 70% of its
  • C. elegans has undetectable levels of 5mC (28). C. elegans case, the F2 generation is still directly exposed since the
  • distributed across the genome at a low level (~ 0.01% of ade- enced regulatory mark; however, further experiments will
  • still need to be confirmed. Going forward, epigenomic edit- notype is heritable across multiple generations (62). Intrigu-
    1. Boulias K, Greer EL. Means, mechanisms and consequences of 61. Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB,

Methods (brief)

  • tible to both artefacts and contamination of samples. This in fertility (58), which may explain the transgenerational
  • to a purified small RNA isolated from P. aeruginosa, P11, numbers of histone PTMs using mass spectrometry can be
    1. Bianco-Miotto T, Craig JM, Gasser YP, van Dijk SJ, Ozanne SE. 24. Leung MCK, Goldstone JV, Boyd WA, Freedman JH, Meyer JN.
    1. Slice LW, Freedman JH, Rubin CS. Purification, characteri- doi.​org/​10.​1289/​ehp.​10029​55.
    1. Freedman JH, Slice LW, Dixon D, Fire A, Rubin CS. The novel Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res
    1. Cui Y, McBride SJ, Boyd WA, Alper S, Freedman JH. Toxi- exposure to 50 parts-per-billion arsenic influences histone modi-
    1. Boyd WA, McBride SJ, Freedman JH. Effects of Genetic Muta- Arsenite Are Associated with H3K4 Dimethylation and SPR-5
    1. Sengupta T, Ange JS, Moore R, Kaletsky R, Marogi J, Myhrvold of small samples and single cells. Nat Commun. 2019;10:1930.

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

Verification notes

  • Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing wiki/sources/ pages before creation.
  • Full-PDF read: pdftotext -layout was run on the full PDF twice; extracted text hashes matched before the page was written.
  • Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
  • Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
  • HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.

CommitDateChangeDescription
b01ec52c2026-08-04major2 sections added
d49e450f2026-08-03major5 sections added; narrative text revised