Maternal environmental exposure and early-life

Overview

This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.

Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

• (42%), with toxic metals (33%) and endocrine disrupting chemicals (EDCs) (20%) as the primary exposures.
• velopmental/behavioral disorders (42%) and adverse birth outcomes (32%) were the predominant endpoints.
• inal research article (n = 1), irrelevant
• (n = 1), and lack of toxin assessment
• other outcomes. Maternal exposure to pesticides has been asso- Sample sizes ranged from 97 to 1,229,566 participants. The
• ciated with neurodevelopmental disorders,14 spontaneous abor- study with the largest sample size (n = 1,229,566) was from the
• has been associated with PTB, LBW, SGA, and term low birth in China25 (Table 1; Figure 2).
• Table 1. Summary of studies on the interaction between environmental exposures and nutrients/supplements in relation to adverse early-life outcomes
• et al.26 (296 cases, logistic ↓ FA (aOR = 2.5 (95%
• et al.27 cohort linear (95% CI: 1.0, 2.6))
• et al.28 (346 cases, based logistic (95% CI: 0.69, 2.75))
• et al.30 mother-child sample) behavior regression (95% CI: 1.1, 5.5))
• et al.31 cohort Start child pairs impairment linear − 1.6 (95% CI: − 6.9,
• Table 1. Continued
• spatiotemporal sample) and Poisson (95% CI: 3.66, 19.09)),
• Table 1. Continued
• et al.36 cohort residential sample) ART mixed- 0.75 (95% CI: 0.53,
• mothers remote- proportional (95% CI: 1.56, 1.67))
• based regression 0.27 (95% CI: 0.21,
• et al.37 birth child pairs (biological kernel status (RR = 1.94 (95%
• et al.38 cohort birth child pairs sample) linear and (41% lower risk of
• et al.39 cohort birth child pairs sample) regression (34% lower risk of
• Table 1. Continued
• monitoring symptoms regression (OR = 0.57 (95% CI:
• cohort child pairs diseases regression 0.44, (95% CI: 0.21,
• Table 1. Continued
• et al.46 child pairs (FFQ) mixed- (β = 0.37, 95% CI:
• et al.50 logistic (95% CI: 0.78, 1.01))
• Davidson Seychelles cohort N/A 229 mother- hair MeHg PUFA neurodevelopmental multiple MeHg (↑ 1 ppm)
• Table 1. Continued
• child pairs (biological disorder regression (95% CI: 0.101, 0.421))
• et al.55 and hair (biological disorder regression (95% CI: − 0.36,
• birth cohort child pairs model (biological regression 3.02 (95% CI: 1.41,
• 10 Table 1. Continued
• et al.61 cohort Adriatic (biological logistic (95% CI: 1.02, 6.41))
• et al.62 cohort child pairs (biological diseases regression 0.91 (95% CI: 0.87,
• (biological linear (95% CI: − 7.3, 214.4))
• Table 1. Continued
• groups, general linear FEF50 (SE = 1.59 (95%
• cohort Birth Cohort child pairs (biological problems g-computation D (β = -0.065 (95% CI: –
• Table 1. Continued
• et al.70 (2,504 cases, air monitoring nutrients hierarchical (OR = 3.23 (95% CI:

Methods (brief)

• A systematic search strategy was developed to identify studies investigating country, study period, study design, sample size, sample type, study method,
• other outcomes. Maternal exposure to pesticides has been asso- Sample sizes ranged from 97 to 1,229,566 participants. The
• ciated with neurodevelopmental disorders,14 spontaneous abor- study with the largest sample size (n = 1,229,566) was from the
• study year Country Design Study Sample size method exposures method) outcomes analysis Effect estimates
• et al.29 cohort mother-child based air sample) linear points in IQ scores
• et al.30 mother-child sample) behavior regression (95% CI: 1.1, 5.5))
• study year Country Design Study Sample size method exposures method) outcomes analysis Effect estimates
• Patti Canada prospective MIREC 364 mother- urine arsenic folate (biological neurodevelopmental multinomial DMA + RDA of FA
• et al.32 cohort child pairs sample) disorders and regression decreased likelihood of
• et al.34 Viva sample) linear PFOA + ↓ folate (β =
• spatiotemporal sample) and Poisson (95% CI: 3.66, 19.09)),
• study year Country Design Study Sample size method exposures method) outcomes analysis Effect estimates
• et al.36 cohort residential sample) ART mixed- 0.75 (95% CI: 0.53,
• cohort sample) machine CI: 1.49, 2.53))
• et al.38 cohort birth child pairs sample) linear and (41% lower risk of
• et al.39 cohort birth child pairs sample) regression (34% lower risk of
• study year Country Design Study Sample size method exposures method) outcomes analysis Effect estimates
• et al.41 Netherlands cohort R Study sample) PTB linear and supplemental FA

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

• Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
• Mercury
• Mercury
• Cadmium
• Lead
• Arsenic

Verification notes

• Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing wiki/sources/ pages before creation.
• Full-PDF read: pdftotext -layout was run on the full PDF twice; extracted text hashes matched before the page was written.
• Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
• Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
• HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.