Exploring the Association between Arsenic Exposure and Sperm

Overview

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Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

• Sheffield, Sheffield, England studies, pooled mean semen volume (3.18 ml; 95% confidence interval (CI): 2.34–
• Introduction around 30% of infertility is accounted to male factors.
• arsenic concentration of 10 µg/L in drinking water.(13) In in formulating public health policies aimed at reducing
• are usually below 5 µg/L, and urinary arsenic levels are light of this, the objective of this systematic review
• generally <10 µg/L.(14) Heavy metals exert negative effect was to scientifically evaluate the evidence underlying
• hormonal imbalance (decrease in testosterone, LH and terms, was used for search (Supplementary Table 1).
• screening independently of title and abstract as per the sperm motility (≥40%) and sperm morphology (≥4%).
• The pooled mean was estimated at 3.18 ml (95%
• design, study location, sample size, exposure (Arsenic (I² = 86.5%, P = 0.0065), indicating substantial variability
• The pooled mean was 78.69 × 10 /mL (95% CI: 6 of this estimate.
• of − 3.53–160.90. Notably, no statistical heterogeneity was The pooled mean was 52.13% (95% CI: 29.88–74.37;
• detected (I² = 0.0%, P = 0.5891), suggesting consistent P < 0.0001), with an exceptionally wide prediction
• Xu et al., China Cross‑sectional Age=32±4.8 years n=96 July 2009– Asi=4.03±3.67 DMA concentration above (33)
• 2012 observational BMI=23.5±3.3 kg/m2 August 2010 AsB=7.49±24.8 the median associated with
• Oguri Japan Cross‑sectional Age=36.8±5.4 years n=42 January 2010– AsV=0.549±0.834 No correlation found (34)
• uncertainty. Heterogeneity was considerable (I² = 95.0%, Shen et al., 2013: In this study, selection criteria
• been presented in Supplementary Table 2. concentration, motility and morphology, suggesting
• recommended 10 µg/L threshold as for acceptable levels Not Applicable.
• Supplementary Table 1: Search Strategy Supplementary Table 2: Risk of biased for cross
• Supplementary Table 3: Risk of biased for case control study using the Newcastle‑Ottawa Scale

Methods (brief)

• dimethylarsinic acid (DMA) and arsenobetaine (AsB). Results
• (PMI = MMA/Asi) or secondary (SMI = DMA/MMA). studies
• The following data were collected: citation, study A high degree of heterogeneity was observed across studies
• design, study location, sample size, exposure (Arsenic (I² = 86.5%, P = 0.0065), indicating substantial variability
• Author Country Study design Participant Sample size Duration of Urinary arsenic Reproductive parameters Reference
• and year characteristics sample concentration (µg/g
• Xu et al., China Cross‑sectional Age=32±4.8 years n=96 July 2009– Asi=4.03±3.67 DMA concentration above (33)
• infertile couple DMA=20.9±13.7
• infertile couple DMA=20.6±14.1
• Author Country Study design Participant Sample size Duration of Urinary arsenic Reproductive parameters Reference
• and year characteristics sample concentration (µg/g
• AsiV, AsB, MMAV, DMAV,
• DMAV=22.78±34.78 were significantly high and
• AsiV/AsiIII=Arsenic redox potential, AsB=Arsenobetaine, BMI=Body mass index, DMA=Dimethylarsinic acid, MMA=Monomethylarsonic Acid, AsiV=Pentavalent arsenic, PMI=Primary
• methylation indices, SMI=Secondary methylation indices, AS=Total Arsenic, Asi=Total Inorganic arsenic, AsiIII=Trivalent arsenic, PMI=MMA/Asi, SMI=DMA/MMA, As=AsiIII + AsiV
• • A sB + MMA + DMA, Asi=AsiIII + AsiV
• Xu et al., 2012, reported that DMA concentration measurement bias. Overall, the study design and
• AsB, MMAV and DMAV were measured. Result showed

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

• Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
• Baby Sunscreen, Mineral (ZnO + TiO2)
• Mercury
• Cadmium
• Arsenic
• Chromium

Verification notes

• Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing wiki/sources/ pages before creation.
• Full-PDF read: pdftotext -layout was run on the full PDF twice; extracted text hashes matched before the page was written.
• Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
• Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
• HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.