Overview
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Key numbers
The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:
- approximately 10% and 20%, respectively, were detected. These results indicate that the oral intake
- high concentrations of total mercury in urine (0.51 µg/L) and hypertension in the United
- (62% increase in odds) (18).
- signal cardiovascular derangement. Cambier et al. (30) reported that after 49 days of feeding
- was reduced by 60 ± 18%, and a substantial loss of the coupling capacity between oxygen
- (~30%) and an increase in reactive oxygen species production (~5-fold change) in AC16
- (Methylmercury(II) chloride PESTANAL® Merck analytical standard, purity > 97.8%) by
- for 5 min with Hg-free(1%
- recovery 99%. of Thethe analysedvalue
- µg.kg −1, and we detected 704 ± 11 µg.kg−1, corresponding to a recovery of 101%. All MeHg
- Finally, carboxyatractyloside was titrated over the range of 5 to 1000 nM, and 5.0 mM
- Proteins of control and MeHg70 heart tissues (10 µg sample/lane, N = 3 animals
- per group) were separated via 15% SDS polyacrylamide gel electrophoresis and trans-
- 5% non-fat dry milk in TBS + 0.05% Tween 20 (TBS-T) and incubated overnight at 4 ◦ C
- tion; Sigma–Aldrich V9131), which was used as a loading control, diluted in 5% non-fat
- lower for animals from the MeHg70 group than for those in the control group (N = 25 per
- which is typical for their age (Table 1). Our results are consistent with those reported by
- A reduced survival rate was also observed in the MeHg70 group (46.4%) when com-
- pared to the control group (95.23%) (Table 1). Only one animal from the control group died
- Table 1. Systemic MeHg toxicity parameters and MeHg concentration in heart samples.
- Survival rate (%) (N = 25) 100 95.23 46.40
- results (Table 3). LV systolic stress is the initial result of alterations in the ability of the
- Figure 2. (A) Blood haemoglobin (g/dL, N = 5): (B) Serum total cholesterol (mg/dL, N = 5); (C) Atrial
- 18 (MeHg70 group); (B) Peak oxygen consumption (VO2). N = 39 (pretest), 18 (control group), 19
- 18 (MeHg70 group); (B) Peak oxygen consumption (VO2 ). N = 39 (pretest), 18 (control group),
- animals 30% less30%
- animalsTheare shown in Table 2. results
- animals are shown in Table 2. Compared with the control animals, the MeHg70-treated This finding
- Table 2. Electrocardiography measurements.
- Table 3. Echocardiography measurements.
- E/A = E wave/A wave ratio. (N = 8). for * p < 0.05; ** p < 0.01; *** p < 0.001 when data from animals from the
- was 50% lower in the MeHg70 group than in the control group (p < 0.05, Figure 5C). The
- control ratio was reduced by 30% in the MeHg70 group relative to the control group,
- (malo), and potassium cyanide (KCN); ww = wet weight. (N = 9) * p < 0.05. (C–G) High-resolution
- The bars represent means ± SEs. N = 9, * p < 0.05, ** p < 0.01 when data from animals from the
- Citrate synthase (CS, U.mg−1.min−1), N= 4 1042 ± 332.1 1106 ± 97.9
- Citrate synthase (CS, U.mg−1 .min−1 ), N= 4 1042 ± 332.1 1106 ± 97.9
- Succinate dehydrogenase (SD, (pmol.mg−1. s−1)/CS/g wet tissue), N = 6 14.53 ± 4.08 14.83 ± 5.42
- Succinate dehydrogenase (SD, (pmol.mg−1 .s−1 )/CS/g wet tissue),−1N = 6 14.53 ± 4.08 14.83 ± 5.42
- ATPase activity of complex V responsive to azide (ATPase, U.mg /CS), N = 4 4.45 ± 0.8 3.21 ± 0.7
- mice (N = 3 animals per group). Immunoblots for respiratory complexes (A,C,E,G,I), ANT (K) and
- assessing the stateanofincrease of 20%viaincalcium
Methods (brief)
- consumption in the two settings. In cardiac tissue samples in oxygraphy studies, this reduction was
- 4.0/). samples from riverside residents (6–8).
- MeHg bioaccumulation has been detected in samples of fishes consumed by the Ama-
- xylazine. Heart tissue samples were collected for high-resolution oxygraphy (Oxy), as well
- assesscollected to assess
- concentration analyses. Additionally, in cardiac tissue samples, mitochondrial function
- Additionally, in cardiac tissue samples, mitochondrial function was evaluated by high-resolution was
- Heart tissue samples from both groups were obtained after euthanasia under anaesthe-
- Paulo, Brazil) for 5 h with gentle stirring every hour. The samples were kept in the dark to oven at 70 °C (Nova
- Ethylmethylmercury sample and 50
- autosampler (33). The
- autosampler (33). The were ensured
- samples. µg.kg −1 , corresponding to a recovery of 99%.
- results of the analysed samples are presented in mg.kg−1.
- Quantitative hearts were collected, and the tip of each
- heart (samples with about 20 mg of tissue) was cut off with a scalpel and placed in ice-
- Immediately after euthanasia, animals’ hearts were collected, and the tip of each
- heart (samples with about 20 mg of tissue) was cut off with a scalpel and placed in ice-
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