probe upon interacting with the target. The sensor was systematically characterized using alternating

Overview

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Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

creativecommons.org/licenses/by/ of 30 µg/L (~126 nM) for uranium in public drinking water in 2003 (6). However, the
ivDde group, the resin was mixed with 2% hydrazine in dimethylformamide. All other
reverse phase column (30 × 250 mm) using an eluent of 0.1% TFA in water (A) and
80% acetonitrile in water (B). The peptides were eluted with a successive linear gradient of
in an electrochemical cell with 2 mL of Phys2 buffer. These sensors were stable for ~10 h,
An equilibration time of 47 min was used for all nine data points. The LOD is the lowest
s/n = 3) from the signal fluctuation in the absence of the target (27). In addition to U(VI), the
78% SS in the MB peak current. This large signal attenuation alludes to favorable 78%
standard solution, which was made in 3% nitric acid. In this case, the initial
amount of 3% nitric acid without U(VI) also resulted in a similar change in the MB an
equal amountInof 3%
is consistent with the behavior of other “signal-off” sensors (40,41). The change in %SS
%SS with frequency was also determined for the U-pT-12 sensor. As can be seen in F
inset. The LOD for U(VI) was 50 nM, and the dynamic range
in the inset. The LOD for U(VI) was 50 nM, and the dynamic range was fro was from
was 75%, which(Figure 4B).
was 75%, which corresponds to a target recovery rate of 96%. The disparities in pH and Hg(II)
a 50% init in
be 99% (Figure to hasbeaIt
99% was affinity
was 75%, which corresponds to a target recovery rate of 96%. The disparities in pH
ionic strength between the pure buffer and the 50% aquifer sample could be the re
for drinking water analysis, we tested it in a 50% synthetic drinking water sample
The sensor responded well to U(VI) (77% SS), and the target recovery rate was estim
to be 99% (Figure 5B). It was also regenerated using the aforementioned method. Ov
SPCE (Figure S5). The sensor responded to U(VI), but the signal attenuation (72% SS)
recovery was close to 100%. Despite the aforementioned differences, we have demonstrated
Table 1 shows the key analytical properties of the U-pT-12 sensor and several pre-
Table 1. A comparison of the key analytical properties of the U-pT-12 sensor and other U(VI) sensors
1. Wu, Y.; Lai, R.Y. An electrochemical gold(III) sensor with high sensitivity and tunable dynamic range. Anal. Chem. 2016, 88,

Methods (brief)

and Cr(VI). Its reusability and ability to function in diluted aquifer and drinking water samples were
mass spectrometry (7,8), UV spectrophotometry (9–11), fluorescence spectroscopy (12),
have achieved low limit of detections (LODs), they either require multistep detection
cost-effective, and compatible with complex sample matrices.
samples (23,24). While there are many examples of DNA (E-DNA)-based metal ion sensors,
complex samples in a simple and cost-effective manner. It also highlights the benefits
non-standard and non-protein AAs, in designing metal ion sensors (35).
50% synthetic aquifer and drinking water samples. The synthetic aquifer sample contained
sample was subsequently diluted with a Phys2 buffer in a 1:1 ratio. The synthetic tap
water sample contained 30 mg L−1 calcium, 0.02 mg L−1 iron, 9.0 mg L−1 magnesium,
0.14 mg L−1 phosphorous (38). This sample was further diluted with a 2x Phys2 buffer in a
first coupled to an insoluble resin support, followed by the remaining AAs, and a
ether. The crude materials were purified by preparative HPLC on a Kromasil 100-10-C18
purified peptides were lyophilized. This one-step purification by reverse-phase HPLC was
An equilibration time of 47 min was used for all nine data points. The LOD is the lowest
inset. The LOD for U(VI) was 50 nM, and the dynamic range
in the inset. The LOD for U(VI) was 50 nM, and the dynamic range was fro was from
Kd was estimatedmatedto be 971(±147)

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Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.

Commit	Date	Change	Description
b01ec52c	2026-08-04	major	2 sections added
d49e450f	2026-08-03	major	5 sections added; narrative text revised