Heavy Metal Index
Ask the IndexAboutIndex Pro

Methylmercury-Mediated Oxidative Stress and

This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus.

Cite this pageVersion history

Overview

This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.

Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

  • directly to the accumulation of Hg in tissues. In a MeHg-exposed subacute rat model (20 ppm MeHg in
  • toxicity than females. The recent study on litters from dam mice exposed to MeHg (5 ppm MeHg
  • that MeHg treatment (orally administered at 5 mg/kg/day for 12 days) decreased mitochondrial
  • shown to be mainly composed of excitable cells (92), suggesting that the characteristic of neuronal
  • (20 ppm MeHg in drinking water every day for 28 days) that showed neuropathological changes
  • Table 1. In vivo protection against methylmercury (MeHg) toxicity.
  • MeHg-induced oxidative stress has been demonstrated in rats, which were treated with 5 mg/kg
  • MeHg for 12 consecutive days and 150 mg/kg α-tocopherol for 20 consecutive days after initial MeHg
  • Co-treatment with Trolox protected MeHg-treated rat skeletal muscle (20 ppm MeHg in drinking water

Methods (brief)

  • micro-dissected mouse cerebral cortex samples and immunohistochemistry revealed that lower basal
  • expression analyses using laser micro-dissected mouse cerebrocortical neuron samples also revealed
  • of flight mass spectrometry (MALDI-TOF/MS) analysis, suggesting that PDI is a target protein for
  • burden for a period of several months prior to sample collection, and the fetal umbilical cord is useful to
  • in addition to the MeHg burden. An assessment of MeHg in preserved umbilical cords collected in
    1. Freedman, R.B.; Klappa, P.; Ruddock, L.W. Protein disulfide isomerases exploit synergy between catalytic
    1. Walsh, J.J.; Friedman, A.K.; Sun, H.; Heller, E.A.; Ku, S.M.; Juarez, B.; Burnham, V.L.; Mazei-Robison, M.S.;

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

Verification notes

  • Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing the linked reference record pages before creation.
  • Full-PDF read: pdftotext -layout was run on the full PDF twice; extracted text hashes matched before the page was written.
  • Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
  • Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
  • HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.

Update history

No substantive edit history is available in this build. The full commit record is available in git.

Referenced by