Methylmercury Risk Assessment Based on European Human

Overview

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Key numbers

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• HBM datasets were selected: HBM studies (n = 18) with mercury (Hg) levels (blood and hair, total
• intake (TWI) for MeHg of 1.3 µg/kg of body weight (4). The Human Biomonitoring Com-
• for total Hg in blood for children and adults of 5 µg/L(HBM-I) and 15 µg/L (HBM-II),
• organic, inorganic and elemental mercury, with MeHg accounting for around 60–91% (16).
• non-invasive sample for estimating long-term average exposure to MeHg since 89–91% of
• range of 18 to 50 years old were selected as relevant population groups for this RA.
• as geometric mean (GM) and/or 95th percentile (P95), and 2) with participants from at
• HQ calculation. In this case, the HBM-I value for total Hg in blood, 5 µg/L, was selected
• 1.3 µg/kg body weight (b.w.), expressed as Hg. In order to evaluate the chronic exposure
• per day (0.1 µg/kg b.w./d) by an adult woman results in hair Hg concentrations of about
• 1.3 µg/kg b.w for MeHg, equivalent to a TDI of 0.19 µg/kg b.w./d, corresponds to hair
• Table 1. Human biomonitoring (HBM) studies with Hg and MeHg data in blood and hair in the
• and a range of P95 of MeHg and/or Hg blood concentrations was compiled (Table 2). As
• the study by Esteban et al. (20), focused on European populations, the geometric mean hair
• Table 2. Range of geometric means (GM) and/or 95th percentiles (P95) of MeHg and/or Hg con-
• Most of the studies did not perform Hg speciation analysis (Table 1); therefore, we
• in the case of the Belgian FLESH study (27), 63% and 74% of the total Hg in hair was in
• value for Hg in blood of 5 µg/L (Equations (2) and (3)), following a conservative approach
• Hg blood concentrations retrieved in the selected HBM datasets (Table 2) and the HBM-I
• Selected internal threshold (HBM − GV of 5 µg/L)
• Table 3 shows the HQ calculations for the GM and/or P95 of Hg levels in blood for
• the range of GM and P95 of all the P95 of HBM
• Table 3. HQ calculations for the GM and/or P95 of Hg levels in blood for all HBM studies considered
• Table 3 shows the HQ calculations for the GM and/or P95 of Hg levels in blood for the
• range of GM and P95 of all the studies together for the selected
• Table 3. HQ calculations for the GM and/or P95 of Hg levels in blood for all HBM studies considered
• and HQP95 BIOVAL =0.212.32, Supplementary Table
• The HQs for DEMOCOPHES study, both for the range of GMs of the 17 individual
• to the value of 1range
• and HQP95 BIOVAL = 2.32, Supplementary Table S1).
• Toxics 2022, 10, 427 For women of childbearing age, the HQ calculated for the range of GMs and P95 10 ofin16
• the children/adolescents, both the upper part of the range of GMs of the 17 individual to or exceeding
• the TWI for MeHg of 1.3 µg/kg b.w established by EFSA (detailed in Section 2.3).
• in the southern European countries (up to 11% in Portugal) were potentially at risk for
• as surrogate of MeHg analysis, due to the high percentage (89–91%) of this
• accounts for a high proportion (60–91%) of the total Hg in blood in general population
• southern European countries (up to 11% in Portugal) were potentially at risk for a MeHg
• and Table S1: Hazard Quotients calculated for each study included in this risk assessment.

Methods (brief)

• non-invasive sample for estimating long-term average exposure to MeHg since 89–91% of
• for searching, accessing and retrieving chemical occurrence data collected and managed
• Mothers analysis of the hair samples (46). In DEMOCOPHES, a total of 1875
• 17 whole study (DEMOCOPHES-17)) of samples collected from September 2011 to February
• measures in the chemical analysis of the hair samples (46). In DEMOCOPHES, a total of
• whole study (DEMOCOPHES-17)) of samples collected from September 2011 to February
• resentativeness of the data collected is limited. In addition, we observed that data from
• percentages seem to be higher although they cannot be calculated as the number of samples
• Spaintheandmain MeHgwhich
• the blood of Koreans by using cold vapor atomic fluorescence spectrophotometry. Ann. Lab. Med. 2012, 32, 31–37. (CrossRef)
• Mercury levels in blood, urine and hair in a nation-wide sample of Spanish adults. Sci. Total Environ. 2019, 670, 262–270.

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

• Fish — marine, predatory (tuna, swordfish, shark, king mackerel)
• Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
• Mercury
• Mercury
• Cadmium

Verification notes

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Update history

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