Role of Mercury Toxicity in Hypertension, Cardiovascular Disease,

Overview

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Key numbers

The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:

• ganic, and organic (Table I).1–5 Dental amalgams are biomethylation to methyl mercury, which is found in
• Institute, 4230 Harding Road, Suite 400, Saint Thomas Medical Plaza, However, 12% of women have hair mercury above the
• Homeostasis GSH (> 50%) Lipid of
• composed of 50% mercury, 25% silver, and 25% tin, intake of selenium reduces mercury-related CVD and
• osol (50% mercury) as a preservative would give an esti- with NADH dehydrogenase causing displacement of
• other heavy metals.9–11 Mercury has no known physi- thione by more than 50%, increased lipid peroxidation
• ologic role in human metabolism, and the human body markers such as TBARS by more than 70%, oxidation
• glutathione (GSH), which provide about 10% to 50% peroxidation include the Fenton reaction, affinity for
• platelet aggregation,33 increases in Factor VIII, platelet mitochondrial dysfunction (Table III). All of these
• incidence of hypertension, 1.17-time increased risk of to total mortality (increase 8%), hypertension (increase
• stroke and 1.51-time increased risk in total cardiovas- 46%), CHD (increase 36%), renal disease (increase
• cular mortality, but no increase in CHD. In a study of 55%), and CVA (increase 36%).39 A Finnish study
• first MI.5 There was a 15% higher toenail mercury High hair mercury content increases carotid IMT and
• the control group (95% confidence interval (CI), 5– in mean carotid IMT over 4 years related directly to
• 2.16 in highest vs the lowest quintile (P=.006, 95% 1 lg in hair mercury content equaled a 0.008-mm
• CI, 1.09–4.29). The adipose DHA was directly propor- increase in carotid IMT, a 7.3% increase over the
• tional to the mercury toenail content (P<.001), and mean. There was a 0.042 mm per 4 years in the high-
• an OR of 0.59 in the highest vs the lowest quintile with a 32% greater increase (P<.05). In addition, mer-
• (P=.02; 95% CI, 0.30–1.19). This important study cury hair content was proportional to blood pressure
• lowest quartile of mercury was associated with a 67% tion consuming one meal per week as fish.64 In
• mercury miners had a 46% greater incidence of and proteinuria, which contribute to sodium retention
• content, hypertension, and carotid IMT.13 In a study 55%.39 Mercury concentrates in the renal tubules and
• (95% CI, 0.36, 3.30; interaction P=.02). variability, increased carotid IMT and carotid artery

Methods (brief)

• times in 833 patients.59 In a sample of 1240 women effects of mercury include increases in oxidative stress
• provoked samples. trations cause oxidative stress and endothelial dysfunction in con-

Implications

This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.

Wiki pages this source may touch

• Fish — marine, predatory (tuna, swordfish, shark, king mackerel)
• Fish — marine, non-predatory (sardines, anchovies, salmon, cod)
• Mercury
• Mercury
• Cadmium
• Arsenic
• Nickel
• Aluminum
• Tin
• Chromium

Verification notes

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Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.