Neuroprotective potentials of extracts from Moringa oleifera and Musa sapientum against cadmium chloride-induced neurotoxicity in rats cerebri

Overview

Akinlolu and colleagues evaluated whether Moringa oleifera and Musa sapientum extracts altered cadmium-chloride-induced neurotoxicity endpoints in rat cerebrum. This is lane a4 toxicology and co-treatment context, not olive-oil occurrence evidence: cadmium chloride was deliberately injected, and olive oil was used as the vehicle for plant-extract administration. The source reports cadmium dose, group size, treatment duration, p-values, and biomarker classes for catalase, superoxide dismutase, COX-2, and cytochrome P450 in rat cerebrum.

Key numbers

• Study design: 24 adult male Wistar rats, six groups, 4 rats per group, with post-treatment across Days 1-17.
• Cadmium exposure: 1.5 mg/kg body weight cadmium chloride, single intraperitoneal dose on Day 1 to Groups 2-4 and 6.
• Plant-extract co-treatments: MO11 at 15 mg/kg body weight orally for Group 3; MO11 15 mg/kg body weight plus MS06 7 mg/kg body weight orally for Group 4.
• Vehicle and comparator: olive oil vehicle 1 ml/kg body weight orally for Group 5 for 17 Days; doxorubicin 3.35 mg/kg body weight as a single intravenous dose in Group 6.
• Catalase in rat cerebrum: CdCl2-only Group 2 was non-significantly lower than normal-saline Group 1 (p = 1.00); Group 3 increased non-significantly vs Group 2 (p = 0.21); Group 4 (p < 0.001), Group 5 (p = 0.03), and Group 6 (p < 0.001) were significantly higher than Group 2.
• Superoxide dismutase in rat cerebrum: Group 2 vs Group 1 was not significantly different (p = 0.19); Groups 3, 4, 5, and 6 vs Group 2 were also not significantly different (p = 0.17, p = 0.28, p = 0.16, and p = 0.10, respectively).
• COX-2 in rat cerebrum: CdCl2-only Group 2 was significantly higher than normal-saline Group 1 (p < 0.001); Groups 3, 4, 5, and 6 were significantly decreased vs Group 2, each at p < 0.001.
• Cytochrome P450 in rat cerebrum: CdCl2-only Group 2 was significantly higher than normal-saline Group 1 (p < 0.001); Groups 3, 4, and 5 were significantly decreased vs Group 2 (p < 0.001 for each); Group 6 decreased non-significantly vs Group 2 (p = 0.34).
• Figure captions state that catalase and superoxide dismutase concentrations were reported as mean±SD in U/L, while COX-2 and cytochrome P450 were reported as mean±SD in pg/mL; the exact plotted mean±SD values are not extractable from the text layer.

Methods (brief)

The authors isolated MO11 from Moringa oleifera leaves and MS06 from Musa sapientum suckers after chromatography and LC-MS work described by their earlier studies. Twenty-four Wistar rats were divided into six groups. Cadmium chloride was administered by single intraperitoneal injection, plant extracts were administered orally, olive oil was used as vehicle, and doxorubicin was used as a comparator. Cerebral CAT and SOD were measured by spectrometric methods; COX-2 and P450 were measured by ELISA at 450 nm. Results were presented as arithmetic mean ± standard deviation and compared using the Mann-Whitney U test with 95% confidence interval and p ≤ 0.05.

Implications

Microbiome: No microbiome endpoints.

Related evidence

• Cadmium
• Health

Update history

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