EFSA — Nickel Tolerable Daily Intake (13 µg/kg b.w./day)

Overview

The EFSA CONTAM Panel established a tolerable daily intake for nickel of 13 µg Ni/kg body weight per day in its September 2020 update of the risk assessment of nickel in food and drinking water, anchored on a BMDL10 of 1.3 mg Ni/kg b.w./day for increased post-implantation loss in rats (EFSA Ni 2020). For acute oral nickel exposure, the Panel identified eczematous flare-up reactions in nickel-sensitized humans (systemic contact dermatitis) as the critical effect, with a margin-of-exposure approach using a LOAEL of 4.3 µg Ni/kg b.w. and an MOE threshold of 30 for low health concern (EFSA Ni 2020).

Sources

• EFSA Ni 2020 — EFSA CONTAM Panel, 2020. Update of the Risk Assessment of Nickel in Food and Drinking Water.

References

Works cited in this page’s text, in first-appearance order. This is not the full corpus for this page; it is only what the prose above draws on. The complete set of sources is listed under Sources below. Each title links to its source record, which carries the ingest receipt, the extracted values, and the file hash of the document it was built from.

1. Update of the Risk Assessment of Nickel in Food and Drinking WaterEFSA Panel on Contaminants in the Food Chain (CONTAM) · EFSA Journal 2020;18(11):6268 · 2020 · doi.org/10.2903/j.efsa.2020.6268Government

Update history

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