This is a comment, not a new bioassay. The authors restate their suggested NOAEL of 0.5 ppm for antimony potassium tartrate and an in vitro IC50 of 0.05 mM. They do not reprint the Poon et al. 1998 occurrence or histopathology tables. The NTP intraperitoneal dose they cite (1.5 mg/kg) is from NTP 1992 and is recorded only as a dose they discuss, with that source named.
Key numbers
| Analyte | Matrix | Value | Unit | Statistic | N | Where |
|---|---|---|---|---|---|---|
| Sb | rat drinking water | 0.5 | ppm | suggested NOAEL | p.1 (printed 337) and 2 (printed 338) | |
| Sb | rat drinking water | 50 | ppm | NOAEL proposed by the critiqued review | p.2 (printed 338) | |
| Sb | rat red cells and spleen | 5.0 | ppm | lowest stated drinking-water level with accumulation | p.2 (printed 338) | |
| Sb | erythrocyte enzyme assay | 0.05 | mM | IC50 | p.1 (printed 337) | |
| Sb | rat, intraperitoneal, NTP 1992 | 1.5 | mg/kg | cited lowest dose with increased organ weights | p.2 (printed 338) |
Methods (brief)
Received 26 January 2000. Journal volume 32, pages 337 to 338. They argue that mild reversible changes in liver, thyroid, and spleen should not be dismissed when setting a NOAEL, and they reject moving the NOAEL from 0.5 ppm to 50 ppm.
Detection and reporting: not reported
Basis: drinking-water concentration and in vitro inhibitory concentration, as restated
Evidence fitness
This source can support: the NOAEL the authors continue to recommend for antimony potassium tartrate; the IC50 they restate for two erythrocyte enzymes.
It cannot support: a new drinking-water survey; human exposure estimates; the full dose-response table of Poon et al. 1998.
Limitations
No new tissue concentrations, water concentrations, or animal counts are measured in this letter. Tissue residue statements (accumulation starting at 5.0 ppm; antimony remaining in spleen one month after exposure) are qualitative restatements of Poon et al. 1998 without new numbers beyond 5.0 ppm.
Related evidence
Update history
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