Exosomes from bone marrow stem cells were loaded with cerium dioxide nanoparticles and tested against liver damage caused by the mycotoxin deoxynivalenol in cells and mice. The loaded exosomes had low cytotoxicity, reduced oxidative stress and inflammation, and changed metabolic and signaling pathways.
Key numbers
- Loaded exosomes remained stable in vivo for 72 hours (abstract).
Methods (brief)
Exosome isolation and loading by extrusion, electron microscopy and elemental mapping, cell assays, mouse experiments and multi-omics.
Evidence fitness
Off-topic for dietary exposure: an experimental nanomedicine study that does not support dietary exposure or toxicity claims about cerium.
Limitations
Laboratory material or biomedical study; no environmental, food or human exposure measurements.
Related evidence
Update history
No substantive edit history is available in this build. The full commit record is available in git.