Overview
This case report documents a Japanese patient with severe dermatitis attributed to nickel-palladium cross-reactivity from dental restorations. The dermatitis resolved following complete replacement of all palladium-containing dental alloys with palladium-free alternatives (Aurofluid CPF, Au 71.5%). Patch testing was positive for both nickel and palladium. The case illustrates the clinical significance of Ni-Pd cross-reactivity and the therapeutic impact of dental alloy replacement.
Key numbers
- Replacement alloy: Aurofluid CPF (Au 71.5%), palladium-free
- Patch test: positive for both nickel (Ni) and Pd
- Resolution: complete after replacement of all Pd-containing dental alloys
- Single patient case
Methods (brief)
Case report with clinical documentation. Patch testing performed to characterize metal sensitization profile. Dental restorations systematically replaced with palladium-free alloys. Clinical follow-up to confirm dermatitis resolution.
Implications
This page makes the source discoverable for palladium evidence routing. Demonstrates clinical resolution of systemic contact dermatitis following removal of Pd-containing dental alloys in a Ni/Pd cross-reactive patient, supporting the hypothesis that dental Pd exposure drives systemic sensitization and that alloy substitution is an effective therapeutic intervention.
Related evidence
Update history
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