Rats given sodium dichromate dihydrate in drinking water for 3 months developed raised serum urea and creatinine, more chromium in blood and kidney, oxidative stress markers and kidney tissue damage. Co-treatment with Spirulina platensis reduced these changes.
Key numbers
- Dose: 520 mg/L sodium dichromate dihydrate in drinking water, stated as equivalent to 182 mg/L hexavalent chromium; spirulina 300 mg/kg body weight by gavage (Methods, p. 2).
- Chromium residues in blood and kidney are shown only in a figure; no tabulated values (Results; Figure 6).
Methods (brief)
Four groups (control, spirulina, dichromate, dichromate plus spirulina); serum urea and creatinine; kidney MDA, glutathione and catalase; chromium residues by atomic absorption; histopathology, PCNA and DNA ploidy.
Evidence fitness
Supports kidney toxicity of high-dose hexavalent chromium in drinking water in rats. It does not support effects at environmental concentrations or a human protective use of spirulina.
Limitations
Single high dose; results mainly in figures; small groups (9 per group).
Related evidence
Update history
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