Overview
This in vitro study compared cytotoxicity of commercially pure titanium (cpTi), silver-palladium (Ag-Pd), and nickel-chromium (Ni-Cr) dental alloys on human gingival fibroblasts (HGF) using the MTT assay. Ag-Pd showed significant cytotoxicity relative to control (p=0.01) while cpTi did not (p=0.42). This publication may represent the same experimental dataset as Ellakany et al. 2026 (doi: 10.3390/jcm15145680); review for dataset overlap is recommended.
Key numbers
- cpTi MTT in DMEM: 0.411 (SD 0.005), p=0.42 (not significant vs control)
- Ag-Pd MTT in DMEM: 0.316 (SD 0.006), p=0.01 (significant reduction vs control)
- Ni-Cr MTT in DMEM: 0.213 (SD 0.003), p=0.02 (significant reduction vs control)
- Ag-Pd MTT in artificial saliva: 0.294 (SD 0.002)
- Ni-Cr MTT in artificial saliva: 0.204 (SD 0.003)
- Ag-Pd ranked intermediate between cpTi (least cytotoxic) and Ni-Cr (most cytotoxic)
Methods (brief)
Human gingival fibroblast (HGF) cell culture with alloy disc incubation. MTT assay. Optical density measured at 570 nm. DMEM and artificial saliva media tested in parallel. Statistical analysis with p-values reported per alloy vs control.
Implications
This page makes the source discoverable for palladium evidence routing. Provides early-publication cytotoxicity data for Ag-Pd dental alloy on HGF cells consistent with intermediate biocompatibility. The dataset overlap with ellakany2026 should be reviewed before including both studies in independent meta-analysis.
Related evidence
Update history
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