Overview
This source page is a mechanical bulk-ingest record for a PDF in the research-pulls corpus. It preserves source-level identity, routeable product/analyte scope, and exact extracted numeric lines for later human or fresh-context audit. It does not derive HMTc thresholds, percentiles, or brand-by-brand comparisons.
Key numbers
The worker extracted the full PDF text with layout preservation twice and compared extraction hashes before commit. The following lines are copied from numeric/table-bearing regions of the PDF and retain the source units and wording where legible:
- pathways underlying Cr(VI)-induced toxicity. For tables (GSE16349), normalized, and prepared for
- concordant regulation. annotations. K-means clustering (k = 10) was applied
- MetaCore pathway enrichment analysis was Table S1). In contrast, the downregulated genes were
- Supplementary Table S2). that short-term Cr(VI) exposure triggers an immediate
- transcriptional targets, and negative regulation of Supplementary Table S3). By contrast, the chronic
- Figure S4, Supplementary Table S4). response to Cr(VI).
- K-means clustering (k = 18) further partitioned the compact nucleolar- translational core composed of
- (proteins) derived from Cr(VI)-responsive DEGs. A high-confidence interaction score (≥ 0.7) was applied, and nodes are color-coded by k-means clustering (k = 18). Only
- Supplementary figures and table. 17. Cheng LC, Kao TJ, Phan NN, Chiao CC, Yen MC, Chen CF, et al. Novel
- to M-C.Y.). Meanwhile, we are grateful to the clinical breast cancer. Aging (Albany NY). 2021; 13: 17970.
Methods (brief)
- samples. For GSE24025, comparisons were made 2.6 Protein-Protein Interaction (PPI) Network
- To assess sample distribution and transcriptional Network topological analysis was subsequently
- three-dimensional visualization of sample clustering. network; and (3) closeness centrality. Genes ranking
- Figure 2. Volcano plots comparing chromium (VI)-exposed samples to matched controls. (A) GSE16349; (B) GSE24025-Large colony; (C) GSE24025-Small colony.
- GSE16349, comparing untreated control cells and Cr(VI)-treated cells. Each column represents an individual sample, and each row represents a gene. Expression values are
- GSE24025, comparing untreated control (Ctrl), Cr(VI)-treated large colony, and Cr(VI)-treated small colony groups. Each column represents an individual sample, and each row
Implications
This page makes the source discoverable for category-level evidence routing. Values remain source-native and should be used only with the stated matrix, species, basis, geography, and censoring context from the paper. The page does not convert total mercury to methylmercury or use total arsenic as inorganic arsenic.
Wiki pages this source may touch
Verification notes
- Identity check: DOI, raw handle, candidate cite-key, and SHA-256 were compared against existing
wiki/sources/pages before creation. - Full-PDF read:
pdftotext -layoutwas run on the full PDF twice; extracted text hashes matched before the page was written. - Numeric verification: numeric/table-bearing lines were selected mechanically from the verified extraction and preserved without unit conversion or rounding.
- Brand firewall: the worker skips PDFs when extracted numeric lines appear brand/manufacturer-sensitive; this page contains category-level or species-level evidence only.
- HMTc firewall: no threshold, percentile, pass/fail, clean/dirty, or certification math is stated.
Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.