Summary
The October 2024 ATSDR Toxicological Profile for Nickel is the current US comprehensive toxicology synthesis for nickel. It covers oral and inhalation routes across acute, intermediate, and chronic durations, addresses the carcinogenic risks of nickel compounds (NTP 15th RoC: known human carcinogens) primarily relevant to occupational inhalation, and the non-cancer endpoints (reproductive and developmental effects, systemic contact dermatitis in nickel-sensitized individuals) relevant to dietary exposure.
Provenance notes
Filename Bookshelf_NBK610351.pdf reflects the NCBI Bookshelf identifier; the document is the ATSDR profile, accessible at the standard tp15.pdf URL.
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Update history
The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.
| Commit | Date | Change | Description |
|---|---|---|---|
| a8052bb | 2026-08-09 | major | 4 sections added; narrative text revised |