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Heavy Metal Index

Effects of Dietary Supplements on the Bioaccessibility of Se, Zn and cadmium (Cd) in Rice: Preliminary Observations from In Vitro Gastrointestinal Simulation Tests

Overview

Zhang et al. measured selenium, zinc, and cadmium in steamed rice from Guangxi Province and tested how common dietary supplement additions changed in vitro gastrointestinal bioaccessibility. The source contributes rice occurrence and bioaccessibility context for cadmium, while the supplement additions are mitigation/intervention conditions rather than measurements of supplement contamination.

Key numbers

  • Rice total concentrations: Se 287.11 +/- 6.84 ug/kg, Zn 8.11 +/- 0.94 mg/kg, cadmium (Cd) 63.30 +/- 15.12 ug/kg.
  • Control gastric-phase bioaccessibility: Cd 52.07%, Zn 36.63%, Se 10.19%.
  • Control intestinal-phase bioaccessibility: Zn 26.82%, Cd 18.72%, Se 14.70%.
  • Reported Cd bioaccessibility ranges: 47.05-55.09% during the gastric phase and 15.09-20.58% during the intestinal phase.
  • Reported Zn bioaccessibility ranges: 35.74-39.51% during the gastric phase and 22.35-33.27% during the intestinal phase.
  • Food mass and digestion setup: 1.5 g steamed rice was incubated in 25 mL gastric solution at pH 1.5, 37 C, 100 rpm for 1 h; intestinal digestion added bile extract and pancreatin, adjusted to pH 7, and incubated for 4 h.
  • Replication: five replicates per treatment.
  • Supplement additions to 1.5 g rice: 7.5 ug vitamin B6, 500 ug vitamin C, 75 ug vitamin E, 2 ug folvite/vitamin B9, 60 ug niacin/vitamin B3, 60 ug copper, 150 ug coenzyme Q10, 3.75 mg methionine, or 4 mg procyanidins.
  • Intervention finding: vitamin C significantly increased selenium bioaccessibility, increased zinc bioaccessibility, and reduced cadmium bioaccessibility to some extent; vitamin E, vitamin B6, and vitamin B9 also significantly increased selenium bioaccessibility. Procyanidins, methionine, and coenzyme Q10 significantly reduced selenium bioaccessibility.

Methods (brief)

The study used steamed rice and an in vitro digestion model based on gastric and intestinal simulation fluids. Se, Zn, and Cd were measured by ICP-MS; limits of detection were 0.1-1 ng/g for Se and Zn and less than 0.1 ng/g for Cd. Method accuracy was checked with rice powder certified reference material GBW 10043.

Limitation: this is a preliminary in vitro bioaccessibility experiment, not a dietary intervention trial and not a market survey. The rice concentration value is useful occurrence context for Guangxi rice, while the supplement effects should be treated as bioaccessibility/mitigation evidence.

Implications

Microbiome: Not a microbiome study.

Update history

The five most recent substantive edits to this page, classified major (evidence or structure moved), correction (a published value or statement was wrong and has been fixed), or minor (narrative rewritten without changing the underlying evidence). Each description is derived from what the edit did to this page; the linked commit is the authoritative record, routine regeneration passes are excluded, and the full version history lives in git. When DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.

CommitDateChangeDescription
b01ec52c32026-08-04major1 section added
3171d069e2026-08-02major1 section added
90a2f9a382026-07-30major1 section added and 1 removed; narrative text revised
eaa8eeeed2026-07-27major1 section added
50de6ab212026-07-27minorNarrative text revised