Overview
Marker-corpus ingest from the archived source file.
Evidence fitness
Animal-model exposure paper. It can support arsenic toxicology context and method context for total arsenic measurements in dam milk, pup stomach contents, placenta, and urine. It should not be routed as human food occurrence evidence or as an HMTc benchmark-distribution source.
Key numbers
- C57BL/6 dams were exposed to 10 ppb arsenic in drinking water during gestation and/or postnatal periods.
- Birth-outcome comparisons used 14-17 dams per exposure group according to the Results text.
- Total arsenic concentrations were measured in placenta, dam breast milk, pup stomach contents at postnatal days 10 and 21, and urine.
Methods
Total arsenic was measured by ICP-MS in biological matrices collected from the mouse exposure experiment. The source describes the exposure vehicle as drinking water and reports sodium arsenite dosing at the current U.S. drinking-water standard level.
Implications
Use this source only for source-scoped arsenic exposure/toxicology context. Do not treat mouse dam milk or pup stomach contents as a human breast-milk occurrence dataset. Where the paper reports total arsenic, retain total-arsenic species and do not substitute inorganic arsenic.
Related evidence
Update history
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