Aurisano et al. 2022 — High-throughput mouthing exposure model for children’s products
This JESEE paper develops a high-throughput model for predicting chemical migration from children’s product materials into saliva during mouthing, calibrated on 437 measured migration rates spanning 66 chemical-material combinations (phthalate plasticizers, alternative plasticizers, polybrominated diphenyl ethers, parabens, methylsiloxanes, chlorophenols, fragrances). The model adapts the Ernstoff food-packaging migration framework to mouthed plastics. The paper does not include heavy-metal occurrence data; it is a methodology paper for non-metal contaminants.
Key numbers
- Dataset: n=437 experimental migration rates from 18 published studies; 66 chemical-material combinations (60 chemicals × 5 materials: PVC, polypropylene PP, ethylene-vinyl acetate EVA, silicone, wood).
- Migration rate range (Fig. 1): 1.7 × 10⁻⁶ µg/10 cm²/min for brominated flame retardant BDE-183 in PP to 32.7 µg/10 cm²/min for plasticizer dibutyl phthalate (DBP) in PVC; over 7 orders of magnitude.
- Two age-group exposure scenarios (Table 2): 3-<6 months body weight 7.4 kg; 2-<3 years body weight 13.8 kg. Pacifier average mouthing duration 3.4 min/h (infants), 1.8 min/h (toddlers); 99th-percentile 37.3 / 46.3 min/h. Doll mouthing average 0.5 / 0.4 min/h; 99th-percentile 2.5 / 2.9 min/h.
- Predicted mouthing exposure doses (E_mouthing, µg/kg_bw/d): range 4 × 10⁻⁸ to 252 µg/kg_bw/d. DBP in PVC dolls 21.7-253 µg/kg_bw/d; propylparaben in EVA pacifiers 5.8-224 µg/kg_bw/d.
- Hazard quotients (HQ = E_mouthing / RfD): average scenario 3 of 437 data points exceeded HQ=1 (2,2,4-Trimethyl-1,3-pentanediol diisobutyrate HQ=1.25; diisononyl cyclohexane-1,2-dicarboxylate HQ=1.06 both in PVC dolls; propylparaben HQ=1.39 in EVA pacifiers). Upper-bound mouthing scenario 70 combinations exceeded HQ=1 for 3-<6 mo, 58 for 2-<3 yr.
- Mechanistic model fit R² = 0.85 across all chemical-material combinations.
- Regression-based model (eq. 5): log10 R_mgr = 3.23 + 0.73 log10 D_p + 0.92 log10 C0 - 0.06 log10 K_ow; R² = 0.89.
Methods (brief)
Systematic literature review of chemical migration rates from children’s products into saliva. Migration rates harmonized to µg/10 cm²/min. Two complementary models built: (1) mechanistic material-saliva migration model adapted from Ernstoff food-packaging framework (diffusion-dominated short-term + two-exponential saturation long-term), with two parameters: chemical diffusion coefficient D_p in product (cm²/s) and product-food/saliva partition coefficient K_pf; (2) multiple linear regression model with initial concentration, D_p, K_ms, K_ow, MW as candidate predictors. EtOH equivalency for saliva taken as 20% (no mechanical stimulation) or 50% (in vivo with mechanical agitation, reflecting mouth flesh-saliva). Validation by three-fold cross-validation (excluding chemical group, experiment group, or random tenfold). Limitations stated: only 5 materials in dataset; brominated flame retardants and parabens have order-of-magnitude variability within same chemical-material combination.
Implications
- Certification (HMTc): Limited direct relevance to heavy-metal threshold work. The model is for organic-chemical migration from polymer matrices; metals would require a separate set of model parameters (ion-exchange and complexation rather than partition coefficient). The exposure-scenario framework (mouthing duration, contact area, body weight by age) is reusable for any HMI mouthing-exposure model on metal-containing children’s products.
- Courses: Methodology reference for chemical migration models; pairs with OECD 2024 crafts-and-toys exposure guidance.
- App: Not directly relevant.
Wiki pages this source may touch
- (None directly; methodology only)
Verification notes
- No heavy-metal occurrence data.
metals: []is correct. - Mouthing-duration values (3.4, 1.8 min/h pacifier average; 37.3, 46.3 min/h 99th percentile) are reusable for any metal-mouthing exposure calculation.
- Audit subagent (2026-05-17) added “in PP” matrix attribution to the BDE-183 lower-bound migration rate per p. 96 col 2 of the source (“for the brominated flame retardant 2,2’,3,4,4’,5’,6-heptabromodiphenyl ether (BDE-183…) in PP to 32.7 µg/10 cm²/min…”). Applied.
- Audit subagent (2026-05-17) flagged the E_mouthing,pred lower bound “4 × 10⁻⁸” as wrong, claiming the source says “8 × 10⁻⁸”; verified against PDF p. 99 col 2 — the source clearly reads “E_mouthing,pred = 4 × 10⁻⁸ to 252 µg/kgBW/d.” Finding was a false positive (OCR misread of “4” as “8”). Wiki value retained.
Page history
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