Chandravanshi, Shiv, Kumar 2021 — Developmental toxicity of cadmium in infants and children: a review
This Environmental Analysis Health and Toxicology systematic review by Chandravanshi, Shiv, and Kumar (Indian forensic-science institutions: Faridabad, Greater Noida, Ghaziabad) synthesizes the human and animal literature on developmental toxicity of cadmium during in-utero and early-life exposure in infants and children. The review covers organ-system endpoints (kidneys, liver, heart, nervous system) and identifies the developmental windows during which cadmium exposure produces persistent effects. It is the most-recent comprehensive pediatric-focused Cd developmental toxicology review in the loaded corpus and is the foundational citing reference for HMTc Cd-threshold rationale targeting infant and child populations.
Key conclusions
The review documents that in-utero and early-life cadmium exposure produces health effects associated with kidney, liver, heart, and nervous-system endpoints in both human and animal studies. Specific developmental windows are identified during which Cd exposure produces persistent effects, supporting the case for vulnerable-population-targeted dietary Cd guidance below adult chronic reference values. The review aggregates the multi-decade literature including the China Wuhan in-utero cohort, the Bangladesh maternal-Cd cohorts, and U.S. and European biomonitoring data.
Implications
- Certification: Background context supporting tight HMTc Cd thresholds for IandC product rows. The pediatric developmental-toxicity case is the canonical justification for setting infant-and-toddler dietary Cd limits below adult-targeted reference values, and this review is the recent secondary-synthesis source that consolidates that case.
- Courses: Standard pediatric Cd developmental toxicology reference.
- App: Supports vulnerable-population flagging for in-utero and infant Cd exposure on Cd-bearing matrices (cocoa, root vegetables, rice, leafy vegetables).
Wiki pages updated on ingest
Page history
The five most recent substantive edits to this page. The full version history lives in git; when DOI minting comes online (see schema docs), each entry below will also link to a version-pinned DataCite DOI.
| Commit | Date | Description |
|---|---|---|
| b0f3d38 | 2026-06-12 | batch | corpus rescreen b04 old terminal skips |