{
  "schema_version": "2.0.0",
  "source_index_schema_version": "2.0.0",
  "manifest_kind": "heavy_metal_index_evidence_packet",
  "retrieval_timestamp": "2026-09-26T10:45:25.165Z",
  "page": {
    "slug": "sources/pal2016-uvb-zno-nanoparticle-dermal-penetration-mouse",
    "title": "UVB exposure enhanced the dermal penetration of zinc oxide nanoparticles and induced inflammatory responses through oxidative stress mediated by MAPKs and NF-κB signaling in SKH-1 hairless mouse skin",
    "description": null,
    "page_type": "source",
    "audience": [
      "regulator",
      "researcher"
    ],
    "canonical_url": "https://heavymetalindex.com/sources/pal2016-uvb-zno-nanoparticle-dermal-penetration-mouse",
    "wiki_doi": null
  },
  "content_pin": {
    "status": "unpinned",
    "reason": "Git history and a matching verified prior manifest are unavailable.",
    "content_hash_scheme": "sha256-utf8-authored-markdown-v2",
    "content_hash_description": "Strip leading YAML; remove only generated hmi-page-history and hmi-page-references marker blocks; trim trailing whitespace and append one LF. Other Markdown bytes are preserved.",
    "content_sha256": "4dea3c0c96a48548b45e53645f31e84e7adb65763d70eed7ca14745fabf6f889",
    "content_bytes": 1723,
    "metadata_sha256": "8dd561d5e5fedaa31d279162e1a7acef13cb85ee3fd7ef77fa4c40ec101f55c9",
    "metadata_hash_description": "SHA-256 of recursively key-sorted JSON from parsed YAML, excluding updated and numeric sources (generated display metadata). All other frontmatter fields are included.",
    "published_body_sha256": "dbbb70102a86c9aceda71f578f1490babfdeb9d4bc2e01ccbc1206994d751595",
    "published_body_bytes": 1961,
    "published_checksum_note": "Published-body and full-Markdown checksums describe the build input, including generated display sections. They are not claimed to equal the Git revision's display sections.",
    "markdown_sha256": "06f0952b4e2c09216272cb78bddb9f7e236c6b128c6a4e99d74360dd63aa268f",
    "markdown_bytes": 4000,
    "git_commit_sha": null,
    "last_commit_sha": null,
    "last_commit_date": null,
    "git_remote": "https://github.com/paleofoundation/heavymetalindex",
    "verify_command": null
  },
  "contributing_sources": [
    "sources/danishepa2015-dermal-absorption-nano-tio2-zno-sunscreen",
    "sources/sccs2012-zinc-oxide-nano-opinion-1489-12"
  ],
  "data_downloads": [],
  "ingest_contract": {
    "metadata_complete": false,
    "ingest_complete": false,
    "gaps": [
      "routing_input:products left empty: zinc oxide nanoparticles were applied topically to mice, not as a sunscreen formulation; the study is compromised-skin context"
    ],
    "completion_note": "Metadata completeness alone does not prove extraction, routing, or primary-source coverage. Completed ingest requires its reconciliation and route audits."
  },
  "license": {
    "prose": "CC BY 4.0",
    "structured_data": "EU database rights reserved — see https://heavymetalindex.com/licensing",
    "attribution": "Heavy Metal Index (heavymetalindex.com), Institute of Contaminant Standards. Cite canonical_url or wiki_doi.",
    "contact": "karen@paleofoundation.com"
  },
  "attestation": {
    "for_use": "Citation, regulatory submission, or peer-review supplementary record.",
    "verifiable_by": "This manifest reports build-input checksums but has no verified Git pin. It cannot establish that these page bytes correspond to a named Git revision.",
    "not_a_certification": "This manifest records publication provenance. It does not certify products or independently validate the page's scientific claims.",
    "license_terms": "https://heavymetalindex.com/licensing"
  },
  "generated_at": "2026-09-26T08:32:01.834Z"
}